| UniProt Protein Function: | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. |
| NCBI Summary: | This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9BY44 |
| NCBI GenInfo Identifier: | 209572747 |
| NCBI Gene ID: | 83939 |
| NCBI Accession: | Q9BY44.3 |
| UniProt Secondary Accession: | Q9BY44,Q5QTR2, Q7Z4E9, Q8NFM1, Q96EW9, Q96K81, A8MPS6 B4DF96, B4DQ14, D3DNI9, |
| UniProt Related Accession: | Q9BY44 |
| Molecular Weight: | 62 kDa |
| NCBI Full Name: | Eukaryotic translation initiation factor 2A |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2A |
| NCBI Official Symbol: | EIF2A |
| NCBI Official Synonym Symbols: | CDA02; EIF-2A; MST089; MSTP004; MSTP089 |
| NCBI Protein Information: | eukaryotic translation initiation factor 2A |
| UniProt Protein Name: | Eukaryotic translation initiation factor 2A |
| UniProt Synonym Protein Names: | 65 kDa eukaryotic translation initiation factor 2A |
| Protein Family: | Eukaryotic translation initiation factor |
| UniProt Gene Name: | EIF2A |
