Anti-EHMT2 Antibody (CAB19288)

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SKU:
CAB19288
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EHMT2
Synonyms:
BAT8
Synonyms:
C6orf30
Synonyms:
G9A
Synonyms:
GAT8
Synonyms:
KMT1C
Synonyms:
NG36
Synonyms:
histone-lysine N-methyltransferase EHMT2
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Description

Product Name:EHMT2 Rabbit mAb
Product Code:CAB19288
Size:20uL, 50uL, 100uL
Synonyms:EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, histone-lysine N-methyltransferase EHMT2
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human EHMT2.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A375
Immunogen:Recombinant protein of human EHMT2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10919
Uniprot:Q96KQ7
Cellular Location:Chromosome, Nucleus
Calculated MW:160, 170kDa
Observed MW:160KDa/180KDa
UniProt Protein Function:EHMT2 iso4: Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromatin; nucleus

Molecular Function:protein binding; zinc ion binding; p53 binding; histone lysine N-methyltransferase activity (H3-K9 specific); protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; peptidyl-lysine di-methylation; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; regulation of DNA replication; histone H3-K9 methylation

NCBI Summary:This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Code:Q96KQ7
NCBI GenInfo Identifier:116241348
NCBI Gene ID:10919
NCBI Accession:Q96KQ7.3
UniProt Secondary Accession:Q96KQ7,Q14349, Q5JP83, Q5JQ92, Q5JQA1, Q5JQG3, Q6PK06 Q96MH5, Q96QD0, Q9UQL8, Q9Y331, B0UZY2,
UniProt Related Accession:Q96KQ7
Molecular Weight:1210
NCBI Full Name:Histone-lysine N-methyltransferase EHMT2
NCBI Synonym Full Names:euchromatic histone-lysine N-methyltransferase 2
NCBI Official Symbol:EHMT2  
NCBI Official Synonym Symbols:G9A; BAT8; GAT8; NG36; KMT1C; C6orf30  
NCBI Protein Information:histone-lysine N-methyltransferase EHMT2; H3-K9-HMTase 3; G9A histone methyltransferase; HLA-B associated transcript 8; lysine N-methyltransferase 1C; ankyrin repeat-containing protein; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase
UniProt Protein Name:Histone-lysine N-methyltransferase EHMT2
UniProt Synonym Protein Names:Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9a
UniProt Gene Name:EHMT2  
UniProt Entry Name:EHMT2_HUMAN
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