Anti-EDARADD Antibody (CAB15951)
- SKU:
- CAB15951
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-EDARADD Antibody |
| Antibody SKU: | CAB15951 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGLR TTKQ MGRG TKAP GHQE DHMV KEPV EDTD PSTL SFNM SDKY PIQD TELP KAEE CDTI TLNC PRNS DMKN QGEE NGFP DSTG DPLP EISK DNSC KENC TCSS CLLR APTI SDLL NDQD LLDV IRIK LDPC HPTV KNWR NFAS KWGM SYDE LCFL EQRP QSPT LEFL LRNS QRTV GQLM ELCR LYHR ADVE KVLR RWVD EEWP KRER GDPS RHF |
| Gene ID: | 128178 |
| Uniprot: | Q8WWZ3 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 23kDa/24kDa |
| Observed MW: | 25kDa |
| Synonyms: | EDARADD, ECTD11A, ECTD11B, ED3, EDA3 |
| Background: | This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| UniProt Protein Function: | EDARADD: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF- kappa-B. Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q42.3 Cellular Component: cytosol Molecular Function:protein binding Biological Process: tumor necrosis factor-mediated signaling pathway Disease: Ectodermal Dysplasia 10a, Hypohidrotic/hair/nail Type, Autosomal Dominant; Ectodermal Dysplasia 10b, Hypohidrotic/hair/tooth Type, Autosomal Recessive; Ectodermal Dysplasia 11a, Hypohidrotic/hair/tooth Type, Autosomal Dominant; Ectodermal Dysplasia 11b, Hypohidrotic/hair/tooth Type, Autosomal Recessive |
| NCBI Summary: | This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WWZ3 |
| NCBI GenInfo Identifier: | 124504411 |
| NCBI Gene ID: | 128178 |
| NCBI Accession: | BC128082 |
| UniProt Secondary Accession: | Q8WWZ3,Q5VYJ7, A2VCK5, A8K7B5, B1AL54, B9ZVW5, |
| UniProt Related Accession: | Q8WWZ3 |
| Molecular Weight: | 23,690 Da |
| NCBI Full Name: | Homo sapiens EDAR-associated death domain, mRNA |
| NCBI Synonym Full Names: | EDAR associated death domain |
| NCBI Official Symbol: | EDARADD |
| NCBI Official Synonym Symbols: | ED3; EDA3; ECTD11A; ECTD11B |
| NCBI Protein Information: | ectodysplasin-A receptor-associated adapter protein |
| UniProt Protein Name: | Ectodysplasin-A receptor-associated adapter protein |
| UniProt Synonym Protein Names: | EDAR-associated death domain protein; Protein crinkled homolog |
| Protein Family: | Ectodysplasin-A receptor-associated adapter protein |
| UniProt Gene Name: | EDARADD |
| UniProt Entry Name: | EDAD_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using EDARADD antibody (CAB15951) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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