Anti-EBAG9 Antibody (CAB1935)
- SKU:
- CAB1935
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-EBAG9 Antibody |
| Antibody SKU: | CAB1935 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-213 of human EBAG9 (NP_004206.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-213 of human EBAG9 (NP_004206.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RSGR GRKL SGDQ ITLP TTVD YSSV PKQT DVEE WTSW DEDA PTSV KIEG GNGN VATQ QNSL EQLE PDYF KDMT PTIR KTQK IVIK KREP LNFG IPDG STGF SSRL AATQ DLPF IHQS SELG DLDT WQEN TNAW EEEE DAAW QAEE VLRQ QKLA DREK RAAE QQRK KMEK EAQR LMKK EQNK IGVK LS |
| Gene ID: | 9166 |
| Uniprot: | O00559 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type III membrane protein |
| Calculated MW: | 24kDa/29kDa |
| Observed MW: | 28kDa |
| Synonyms: | EBAG9, EB9, PDAF |
| Background: | This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. |
| UniProt Protein Function: | RCAS1: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases. Homodimer. By estrogen. Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 8q23 Cellular Component: Golgi membrane; Golgi apparatus; focal adhesion; plasma membrane; integral to membrane; secretory granule Molecular Function:apoptotic protease activator activity Biological Process: apoptosis; regulation of cell growth |
| UniProt Code: | O00559 |
| NCBI GenInfo Identifier: | 8928283 |
| NCBI Gene ID: | |
| NCBI Accession: | O00559.1 |
| Molecular Weight: | |
| NCBI Full Name: | Receptor-binding cancer antigen expressed on SiSo cells |
| UniProt Protein Name: | Receptor-binding cancer antigen expressed on SiSo cells |
| UniProt Synonym Protein Names: | Cancer-associated surface antigen RCAS1; Estrogen receptor-binding fragment-associated gene 9 protein |
| Protein Family: | Receptor-binding cancer antigen |
| UniProt Gene Name: | EBAG9 |
| UniProt Entry Name: | RCAS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EBAG9 antibody (CAB1935) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using EBAG9 Antibody (CAB1935) at dilution of 1:100 (40x lens). |
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