| UniProt Protein Function: | E2F4: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Belongs to the E2F/DP family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: nucleoplasm; transcription factor complexMolecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity; transcription factor bindingBiological Process: G1/S-specific transcription in mitotic cell cycle; transcription initiation from RNA polymerase II promoter; organ morphogenesis; transcription, DNA-dependent; blood circulation; transforming growth factor beta receptor signaling pathway; epithelial cell development; gene expression; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; cell volume homeostasis; regulation of cell size; regulation of cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16254 |
| NCBI GenInfo Identifier: | 2494229 |
| NCBI Gene ID: | 1874 |
| NCBI Accession: | Q16254.2 |
| UniProt Secondary Accession: | Q16254,Q12991, Q15328, A6NGR8, B5BU56 |
| UniProt Related Accession: | Q16254 |
| Molecular Weight: | 43,960 Da |
| NCBI Full Name: | Transcription factor E2F4 |
| NCBI Synonym Full Names: | E2F transcription factor 4, p107/p130-binding |
| NCBI Official Symbol: | E2F4 |
| NCBI Official Synonym Symbols: | E2F-4 |
| NCBI Protein Information: | transcription factor E2F4; p107/p130-binding protein |
| UniProt Protein Name: | Transcription factor E2F4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | E2F4 |
| UniProt Entry Name: | E2F4_HUMAN |
