Anti-DYRK2 Antibody (CAB7012)
- SKU:
- CAB7012
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-DYRK2 Antibody |
| Antibody SKU: | CAB7012 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 429-528 of human DYRK2 (NP_003574.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, Jurkat, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 429-528 of human DYRK2 (NP_003574.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GCDD PLFL DFLK QCLE WDPA VRMT PGQA LRHP WLRR RLPK PPTG EKTS VKRI TEST GAIT SISK LPPP SSSA SKLR TNLA QMTD ANGN IQQR TVLP KLVS |
| Gene ID: | 8445 |
| Uniprot: | Q92630 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 59kDa/66kDa |
| Observed MW: | 67kDa |
| Synonyms: | DYRK2 |
| Background: | DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. |
| UniProt Protein Function: | DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3. |
| UniProt Protein Details: | Protein type:Protein kinase, CMGC; Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; CMGC group; DYRK family; Dyrk2 subfamily Chromosomal Location of Human Ortholog: 12q15 Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex Molecular Function:protein serine/threonine kinase activity; ubiquitin binding; protein binding; protein-tyrosine kinase activity; manganese ion binding; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding Biological Process: smoothened signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; negative regulation of NFAT protein import into nucleus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein amino acid phosphorylation; response to DNA damage stimulus |
| NCBI Summary: | DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92630 |
| NCBI GenInfo Identifier: | 148887370 |
| NCBI Gene ID: | 8445 |
| NCBI Accession: | Q92630.3 |
| UniProt Secondary Accession: | Q92630,Q9BRB5, B2R9V9, |
| UniProt Related Accession: | Q92630 |
| Molecular Weight: | 601 |
| NCBI Full Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
| NCBI Synonym Full Names: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| NCBI Official Symbol: | DYRK2 |
| NCBI Protein Information: | dual specificity tyrosine-phosphorylation-regulated kinase 2 |
| UniProt Protein Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
| Protein Family: | Dual specificity tyrosine-phosphorylation-regulated kinase |
| UniProt Gene Name: | DYRK2 |
| UniProt Entry Name: | DYRK2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DYRK2 antibody (CAB7012) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of A-549 cells using DYRK2 antibody (CAB7012). Blue: DAPI for nuclear staining. |
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