Anti-Dynein intermediate chain 1 Antibody (CAB3624)
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주문- SKU:
- CAB3624
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CILD1
- Synonyms:
- DIC1
- Synonyms:
- ICS1
- Synonyms:
- PCD
Frequently bought together:
Description
| Product Name: | Dynein intermediate chain 1 Rabbit mAb |
| Product Code: | CAB3624 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CILD1, DIC1, ICS1, PCD |
| Applications: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Dynein intermediate chain 1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse testis, Rat testis |
| Immunogen: | A synthesized peptide derived from human Dynein intermediate chain 1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 27019 |
| Uniprot: | Q9UI46 |
| Calculated MW: | 79kDa |
| Observed MW: | 79KDa |
| UniProt Protein Function: | DNAI1: Part of the dynein complex of respiratory cilia. Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1). CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAI1 are the cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein intermediate chain family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: cilium; cytoskeleton Molecular Function:protein binding Biological Process: determination of left/right symmetry; sperm motility Disease: Ciliary Dyskinesia, Primary, 1 |
| NCBI Summary: | This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9UI46 |
| NCBI GenInfo Identifier: | 12643888 |
| NCBI Gene ID: | 27019 |
| NCBI Accession: | Q9UI46.1 |
| UniProt Secondary Accession: | Q9UI46,Q5T8G7, Q8NHQ7, Q9UEZ8, B7Z7U1, |
| UniProt Related Accession: | Q9UI46 |
| Molecular Weight: | 79kDa |
| NCBI Full Name: | Dynein intermediate chain 1, axonemal |
| NCBI Synonym Full Names: | dynein axonemal intermediate chain 1 |
| NCBI Official Symbol: | DNAI1 |
| NCBI Official Synonym Symbols: | PCD; DIC1; ICS1; CILD1 |
| NCBI Protein Information: | dynein intermediate chain 1, axonemal |
| UniProt Protein Name: | Dynein intermediate chain 1, axonemal |
| UniProt Synonym Protein Names: | Axonemal dynein intermediate chain 1 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DNAI1 |
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