Anti-DVL2 Antibody (CAB14726)
- SKU:
- CAB14726
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-DVL2 Antibody |
| Antibody SKU: | CAB14726 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human DVL2 (NP_004413.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGS STGG GGVG ETKV IYHL DEEE TPYL VKIP VPAE RITL GDFK SVLQ RPAG AKYF FKSM DQDF GVVK EEIS DDNA RLPC FNGR VVSW LVSS DNPQ PEMA PPVH EPRA ELAP PAPP LPPL PPER TSGI GDSR PPSF HPNV SSSH ENLE PETE TESV VSLR RERP RRRD SSEH GAGG HRTG GPSR LERH LAGY ESSS TLMT SELE STSL GDSD EEDT MSRF SSST EQSS ASRL LKRH RRRR |
| Gene ID: | 1856 |
| Uniprot: | O14641 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Peripheral membrane protein, cytosol |
| Calculated MW: | 78kDa |
| Observed MW: |
| Synonyms: | DVL2 |
| Background: | This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. |
| UniProt Protein Function: | DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; nucleus Molecular Function:frizzled binding; identical protein binding; protein binding Biological Process: heart development; neural tube closure; positive regulation of JNK activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; segment specification; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway |
| NCBI Summary: | This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14641 |
| NCBI GenInfo Identifier: | 6919871 |
| NCBI Gene ID: | 1856 |
| NCBI Accession: | O14641.1 |
| UniProt Secondary Accession: | O14641,Q53XM0, D3DTN3, |
| UniProt Related Accession: | O14641 |
| Molecular Weight: | 78,948 Da |
| NCBI Full Name: | Segment polarity protein dishevelled homolog DVL-2 |
| NCBI Synonym Full Names: | dishevelled segment polarity protein 2 |
| NCBI Official Symbol: | DVL2 |
| NCBI Protein Information: | segment polarity protein dishevelled homolog DVL-2 |
| UniProt Protein Name: | Segment polarity protein dishevelled homolog DVL-2 |
| UniProt Synonym Protein Names: | DSH homolog 2 |
| Protein Family: | Segment polarity protein dishevelled |
| UniProt Gene Name: | DVL2 |
| UniProt Entry Name: | DVL2_HUMAN |
 | Immunofluorescence analysis of U2OS cells using DVL2 antibody (CAB14726) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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