Anti-DUSP8 Antibody (CAB17990)
- SKU:
- CAB17990
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-DUSP8 Antibody |
| Antibody SKU: | CAB17990 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human DUSP8 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:1000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Raji, A-431 |
| Immunogen: | Recombinant protein of human DUSP8 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1850 |
| Uniprot: | Q13202 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 65kDa |
| Observed MW: | 66kDa |
 | Western blot - DUSP8 Polyclonal Antibody (CAB17990) |
| Synonyms: | DUSP8, C11orf81, HB5, HVH-5, HVH8 |
| Background: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. |
| UniProt Protein Function: | DUSP8: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytoplasm; nucleus Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: protein amino acid dephosphorylation; inactivation of MAPK activity |
| NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13202 |
| NCBI GenInfo Identifier: | 223590200 |
| NCBI Gene ID: | 1850 |
| NCBI Accession: | Q13202.2 |
| UniProt Related Accession: | Q13202 |
| Molecular Weight: | |
| NCBI Full Name: | Dual specificity protein phosphatase 8 |
| NCBI Synonym Full Names: | dual specificity phosphatase 8 |
| NCBI Official Symbol: | DUSP8 |
| NCBI Official Synonym Symbols: | HB5; HVH8; HVH-5; C11orf81 |
| NCBI Protein Information: | dual specificity protein phosphatase 8 |
| UniProt Protein Name: | Dual specificity protein phosphatase 8 |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase hVH-5 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP8 |
| UniProt Entry Name: | DUS8_HUMAN |
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