Anti-DUSP22 Antibody (CAB7281)
- SKU:
- CAB7281
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DUSP22 Antibody |
| Antibody SKU: | CAB7281 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human DUSP22 (NP_064570.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human DUSP22 (NP_064570.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGNG MNKI LPGL YIGN FKDA RDAE QLSK NKVT HILS VHDS ARPM LEGV KYLC IPAA DSPS QNLT RHFK ESIK FIHE CRLR GESC LVHC LAGV SRSV TLVI AYIM TVTD FGWE DALH TVRA GRSC ANPN VGFQ RQLQ EFEK HEVH QYRQ WLKE EYGE SPLQ DAEE AKNI LAAP GILK FWAF LRRL |
| Gene ID: | 56940 |
| Uniprot: | Q9NRW4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 20kDa/23kDa |
| Observed MW: | 21kDa |
| Synonyms: | DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX |
| Background: |
| UniProt Protein Function: | DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Apoptosis Chromosomal Location of Human Ortholog: 6p25.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; inactivation of MAPK activity; regulation of cell proliferation |
| UniProt Code: | Q9NRW4 |
| NCBI GenInfo Identifier: | 74752929 |
| NCBI Gene ID: | 56940 |
| NCBI Accession: | Q9NRW4.1 |
| UniProt Secondary Accession: | Q9NRW4,Q59GW2, Q5VWR2, Q96AR1, B4DK56, |
| UniProt Related Accession: | Q9NRW4 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Dual specificity protein phosphatase 22 |
| NCBI Synonym Full Names: | dual specificity phosphatase 22 |
| NCBI Official Symbol: | DUSP22 |
| NCBI Official Synonym Symbols: | VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2 |
| NCBI Protein Information: | dual specificity protein phosphatase 22; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2 |
| UniProt Protein Name: | Dual specificity protein phosphatase 22 |
| UniProt Synonym Protein Names: | JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP22 |
| UniProt Entry Name: | DUS22_HUMAN |
 | Western blot analysis of extracts of BT-474 cells, using DUSP22 antibody (CAB7281) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of A-549 cells using DUSP22 antibody (CAB7281). Blue: DAPI for nuclear staining. |
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