Anti-DUSP10 Antibody (CAB8748)
- SKU:
- CAB8748
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DUSP10 Antibody |
| Antibody SKU: | CAB8748 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DUSP10 (NP_009138.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DUSP10 (NP_009138.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPPS PLDD RVVV ALSR PVRP QDLN LCLD SSYL GSAN PGSN SHPP VIAT TVVS LKAA NLTY MPSS SGSA RSLN CGCS SASC CTVA TYDK DNQA QTQA IAAG TTTT AIGT STTC PANQ MVNN NENT GSLS PSSG VGSP VSGT PKQL ASIK IIYP NDLA KKMT KCSK SHLP SQGP VIID CRPF MEYN KSHI QGAV HINC ADKI SRRR LQQG KITV LDLI SCRE GKDS FKRI FSKE IIVY DENT NEPS RVMP SQPL HIVL ESLK REGK EPLV LKGG LSSF KQNH ENLC DNSL QLQE CREV GGGA |
| Gene ID: | 11221 |
| Uniprot: | Q9Y6W6 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 16kDa/52kDa |
| Observed MW: | 53kDa |
| Synonyms: | DUSP10, MKP-5, MKP5 |
| Background: | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16 Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm; nucleus Molecular Function:MAP kinase phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity Biological Process: inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; protein amino acid dephosphorylation; response to stress |
| NCBI Summary: | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q9Y6W6 |
| NCBI GenInfo Identifier: | 20138090 |
| NCBI Gene ID: | 11221 |
| NCBI Accession: | Q9Y6W6.1 |
| UniProt Secondary Accession: | Q9Y6W6,Q6GSI4, Q9H9Z5, D3DTB4, |
| UniProt Related Accession: | Q9Y6W6 |
| Molecular Weight: | 16,110 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 10 |
| NCBI Synonym Full Names: | dual specificity phosphatase 10 |
| NCBI Official Symbol: | DUSP10 |
| NCBI Official Synonym Symbols: | MKP5; MKP-5 |
| NCBI Protein Information: | dual specificity protein phosphatase 10 |
| UniProt Protein Name: | Dual specificity protein phosphatase 10 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP10 |
| UniProt Entry Name: | DUS10_HUMAN |
 | Western blot analysis of extracts of BT-474 cells, using DUSP10 antibody (CAB8748) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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