Anti-DRD4 Antibody (CAB1337)
- SKU:
- CAB1337
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-DRD4 Antibody |
| Antibody SKU: | CAB1337 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_000788.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_000788.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AWLL SPRL CDAL MAMD VMLC TASI FNLC AISV DRFV AVAV PLRY NRQG GSRR QLLL IGAT WLLS AAVA APVL CGLN DVRG RDPA VCRL EDRD YVVY SSVC S |
| Gene ID: | 1815 |
| Uniprot: | P21917 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 48kDa |
| Observed MW: | 52kDa |
| Synonyms: | DRD4, D4DR |
| Background: | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. |
| UniProt Protein Function: | DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; identical protein binding; protein binding; SH3 domain binding Biological Process: activation of MAPK activity; adult locomotory behavior; arachidonic acid secretion; behavioral response to cocaine; behavioral response to ethanol; cellular calcium ion homeostasis; dopamine metabolic process; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase inhibiting pathway; fear response; negative regulation of adenylate cyclase activity; negative regulation of cAMP biosynthetic process; negative regulation of protein secretion; positive regulation of dopamine uptake; positive regulation of kinase activity; positive regulation of sodium:hydrogen antiporter activity; regulation of circadian rhythm; regulation of dopamine metabolic process; regulation of inhibitory postsynaptic membrane potential; response to amphetamine; synaptic transmission, dopaminergic Disease: Attention Deficit-hyperactivity Disorder; Novelty Seeking Personality Trait |
| NCBI Summary: | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21917 |
| NCBI GenInfo Identifier: | 1345939 |
| NCBI Gene ID: | 1815 |
| NCBI Accession: | P21917.2 |
| UniProt Secondary Accession: | P21917,Q7Z7Q5, Q8NGM5, B0M0J7, |
| UniProt Related Accession: | P21917 |
| Molecular Weight: | 48,361 Da |
| NCBI Full Name: | D(4) dopamine receptor |
| NCBI Synonym Full Names: | dopamine receptor D4 |
| NCBI Official Symbol: | DRD4 |
| NCBI Official Synonym Symbols: | D4DR |
| NCBI Protein Information: | D(4) dopamine receptor |
| UniProt Protein Name: | D(4) dopamine receptor |
| UniProt Synonym Protein Names: | D(2C) dopamine receptor; Dopamine D4 receptor |
| Protein Family: | D(4) dopamine receptor |
| UniProt Gene Name: | DRD4 |
| UniProt Entry Name: | DRD4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DRD4 antibody (CAB1337) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat retina using DRD4 antibody (CAB1337) at dilution of 1:100 (40x lens). |
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