Anti-DPYSL2 Antibody (CAB14570)[KO Validated]
- SKU:
- CAB14570
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Antibody Name: | Anti-DPYSL2 Antibody [KO Validated] |
Antibody SKU: | CAB14570 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HepG2, U-251MG, 293T |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | RIAV GSDA DLVI WDPD SVKT ISAK THNS SLEY NIFE GMEC RGSP LVVI SQGK IVLE DGTL HVTE GSGR YIPR KPFP DFVY KRIK ARSR LAEL RGVP RGLY D |
Gene ID: | 1808 |
Uniprot: | Q16555 |
Cellular Location: | Cytoplasm, Membrane, cytoskeleton, cytosol |
Calculated MW: | 58kDa/62kDa |
Observed MW: | 62kDa |
Synonyms: | DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2 |
Background: | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
UniProt Protein Function: | CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Microtubule-binding Chromosomal Location of Human Ortholog: 8p22-p21 Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol Molecular Function:protein binding; dihydropyrimidinase activity; protein kinase binding Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
NCBI Summary: | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q16555 |
NCBI GenInfo Identifier: | 3122051 |
NCBI Gene ID: | 1808 |
NCBI Accession: | Q16555.1 |
UniProt Secondary Accession: | Q16555,O00424, A8K5H2, B4DR31, D3DSS7, |
UniProt Related Accession: | Q16555 |
Molecular Weight: | |
NCBI Full Name: | Dihydropyrimidinase-related protein 2 |
NCBI Synonym Full Names: | dihydropyrimidinase-like 2 |
NCBI Official Symbol: | DPYSL2 |
NCBI Official Synonym Symbols: | DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2 |
NCBI Protein Information: | dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2 |
UniProt Protein Name: | Dihydropyrimidinase-related protein 2 |
UniProt Synonym Protein Names: | Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 |
Protein Family: | Dihydropyrimidinase-related protein |
UniProt Gene Name: | DPYSL2 |
UniProt Entry Name: | DPYL2_HUMAN |