Anti-DPP8 Antibody (CAB7113)
- SKU:
- CAB7113
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-DPP8 Antibody |
| Antibody SKU: | CAB7113 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-230 of human DPP8 (NP_932065.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, MCF7, NCI-H460, HeLa, Mouse brain, Mouse lung, Mouse skeletal muscle, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-230 of human DPP8 (NP_932065.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IKSG KCNM AAAM ETEQ LGVE IFET ADCE ENIE SQDR PKLE PFYV ERYS WSQL KKLL ADTR KYHG YMMA KAPH DFMF VKRN DPDG PHSD RIYY LAMS GENR ENTL FYSE IPKT INRA AVLM LSWK PLLD LFQA TLDY GMYS REEE LLRE RKRI GTVG IASY DYHQ GSGT FLFQ AGSG IYHV KDGG PQGF TQQP LRPN LVET SCPN IRMD PKLC PADP DWIA F |
| Gene ID: | 54878 |
| Uniprot: | Q6V1X1 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 83kDa/89kDa/97kDa/101kDa/103kDa |
| Observed MW: | 103kDa |
| Synonyms: | DPP8, DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141 |
| Background: | This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | DPP8: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Belongs to the peptidase S9B family. DPPIV subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.14.5 Chromosomal Location of Human Ortholog: 15q22 Cellular Component: nucleoplasm; membrane; cytoplasm Molecular Function:dipeptidyl-peptidase activity; serine-type peptidase activity Biological Process: immune response; proteolysis |
| NCBI Summary: | This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6V1X1 |
| NCBI GenInfo Identifier: | 67460301 |
| NCBI Gene ID: | 54878 |
| NCBI Accession: | Q6V1X1.1 |
| UniProt Secondary Accession: | Q6V1X1,Q7Z4C8, Q7Z4D3, Q7Z4E1, Q8IWG7, Q8NEM5, Q96JX1 Q9HBM2, Q9HBM3, Q9HBM4, Q9HBM5, Q9NXF4, |
| UniProt Related Accession: | Q6V1X1 |
| Molecular Weight: | 898 |
| NCBI Full Name: | Dipeptidyl peptidase 8 |
| NCBI Synonym Full Names: | dipeptidyl-peptidase 8 |
| NCBI Official Symbol: | DPP8 |
| NCBI Official Synonym Symbols: | DP8; DPRP1; MSTP141 |
| NCBI Protein Information: | dipeptidyl peptidase 8; DPRP-1; DPP VIII; dipeptidylpeptidase 8; prolyl dipeptidase DPP8; dipeptidyl peptidase VIII; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase IV-related protein-1 |
| UniProt Protein Name: | Dipeptidyl peptidase 8 |
| UniProt Synonym Protein Names: | Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; Prolyl dipeptidase DPP8 |
| Protein Family: | Dipeptidyl peptidase |
| UniProt Gene Name: | DPP8 |
| UniProt Entry Name: | DPP8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DPP8 antibody (CAB7113) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of A549 cells using DPP8 antibody (CAB7113). Blue: DAPI for nuclear staining. |
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