| UniProt Protein Function: | DPF3: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the requiem/DPF family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 14q24.2 Molecular Function:zinc ion binding Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification |
| NCBI Summary: | This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q92784 |
| NCBI GenInfo Identifier: | 526118057 |
| NCBI Gene ID: | 8110 |
| NCBI Accession: | NP_001267471.1 |
| UniProt Secondary Accession: | Q92784,Q32UJ0, Q6P9E6, Q6ZT41, Q9H7Y5, A8MSI3, B7Z276 F5H575, |
| UniProt Related Accession: | Q92784 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger protein DPF3 isoform 2 |
| NCBI Synonym Full Names: | D4, zinc and double PHD fingers, family 3 |
| NCBI Official Symbol: | DPF3 |
| NCBI Official Synonym Symbols: | CERD4; BAF45C |
| NCBI Protein Information: | zinc finger protein DPF3 |
| UniProt Protein Name: | Zinc finger protein DPF3 |
| UniProt Synonym Protein Names: | BRG1-associated factor 45C; BAF45C; Zinc finger protein cer-d4 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | DPF3 |
| UniProt Entry Name: | DPF3_HUMAN |
