Anti-DOCK7 Antibody (CAB17236)
- SKU:
- CAB17236
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DOCK7 Antibody |
| Antibody SKU: | CAB17236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human DOCK7. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human DOCK7. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 85440 |
| Uniprot: | Q96N67 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | DOCK7, EIEE23, ZIR2 |
| Background: | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. |
| NCBI Summary: | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q96N67 |
| NCBI GenInfo Identifier: | 431822375 |
| NCBI Gene ID: | 85440 |
| NCBI Accession: | NP_001258928.1 |
| UniProt Secondary Accession: | Q96N67,Q00M63, Q2PPY7, Q45RE8, Q45RE9, Q5T1B9, Q5T1C0 Q6ZV32, Q8TB82, Q96NG6, Q96NI0, Q9C092, |
| UniProt Related Accession: | Q96N67 |
| Molecular Weight: | Observed: 242 kDaPredicted: 243 kDa |
| NCBI Full Name: | dedicator of cytokinesis protein 7 isoform 1 |
| NCBI Synonym Full Names: | dedicator of cytokinesis 7 |
| NCBI Official Symbol: | DOCK7 |
| NCBI Official Synonym Symbols: | ZIR2; EIEE23 |
| NCBI Protein Information: | dedicator of cytokinesis protein 7 |
| UniProt Protein Name: | Dedicator of cytokinesis protein 7 |
| Protein Family: | Dedicator of cytokinesis protein |
| UniProt Gene Name: | DOCK7 |
 | Western blot analysis of extracts of various cell lines, using DOCK7 antibody (CAB17236) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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