Anti-DNPH1 Antibody (CAB2382)
- SKU:
- CAB2382
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- C6orf108
- RCL
- dJ330M21.3
Frequently bought together:
Description
| Product Name: | DNPH1 Rabbit mAb |
| Product Code: | CAB2382 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | C6orf108, RCL, dJ330M21.3 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human DNPH1. |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, BT-474 |
| Immunogen: | A synthesized peptide derived from human DNPH1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10591 |
| Uniprot: | O43598 |
| Calculated MW: | 21kDa |
| Observed MW: | 20KDa |
| UniProt Protein Function: | DNPH1: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. Monomer and homodimer. Expression is induced by ETV1. Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. Belongs to the deoxyribonucleoside 5'-monophosphate N- glycosidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.2.2.-; Hydrolase Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein homodimerization activity; nucleoside deoxyribosyltransferase activity Biological Process: cell proliferation; epithelial cell differentiation; nucleoside metabolic process; nucleotide metabolic process; positive regulation of cell growth; deoxyribonucleoside monophosphate catabolic process |
| NCBI Summary: | This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43598 |
| NCBI GenInfo Identifier: | 5454002 |
| NCBI Gene ID: | 10591 |
| NCBI Accession: | NP_006434.1 |
| UniProt Secondary Accession: | O43598,Q80VJ3, O35820, |
| UniProt Related Accession: | O43598 |
| Molecular Weight: | 19,108 Da |
| NCBI Full Name: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 isoform 1 |
| NCBI Synonym Full Names: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| NCBI Official Symbol: | DNPH1 |
| NCBI Official Synonym Symbols: | RCL; C6orf108; dJ330M21.3; RP3-330M21.3 |
| NCBI Protein Information: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; putative c-Myc-responsive; c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase |
| UniProt Protein Name: | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| UniProt Synonym Protein Names: | c-Myc-responsive protein RCL |
| UniProt Gene Name: | DNPH1 |
| UniProt Entry Name: | DNPH1_HUMAN |
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