Anti-DLX5 Antibody (CAB15049)
- SKU:
- CAB15049
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DLX5 Antibody |
| Antibody SKU: | CAB15049 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human DLX5 (NP_005212.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HeLa, mouse brain, rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human DLX5 (NP_005212.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EMPP EHSP SSSD PMAC NSPQ SPAV WEPQ GSSR SLSH HPHA HPPT SNQS PASS YLEN SASW YTSA ASSI NSHL PPPG SLQH PLAL ASGT LY |
| Gene ID: | 1749 |
| Uniprot: | P56178 |
| Cellular Location: | Nucleus |
| Calculated MW: | 20kDa/31kDa |
| Observed MW: | 36kDa |
| Synonyms: | DLX5, SHFM1D |
| Background: | This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. |
| UniProt Protein Function: | DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 7q22 Cellular Component: nuclear chromatin Biological Process: BMP signaling pathway; cell proliferation; endochondral ossification; nervous system development; osteoblast differentiation; positive regulation of transcription, DNA-dependent; skeletal development Disease: Split-hand/foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P56178 |
| NCBI GenInfo Identifier: | 12644329 |
| NCBI Gene ID: | 1749 |
| NCBI Accession: | P56178.2 |
| UniProt Secondary Accession: | P56178,Q9UPL1, B7Z4P3, |
| UniProt Related Accession: | P56178 |
| Molecular Weight: | 20,900 Da |
| NCBI Full Name: | Homeobox protein DLX-5 |
| NCBI Synonym Full Names: | distal-less homeobox 5 |
| NCBI Official Symbol: | DLX5 |
| NCBI Official Synonym Symbols: | SHFM1D |
| NCBI Protein Information: | homeobox protein DLX-5 |
| UniProt Protein Name: | Homeobox protein DLX-5 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | DLX5 |
| UniProt Entry Name: | DLX5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DLX5 antibody (CAB15049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90. |
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