Anti-DLL3 Antibody (CAB18108)
- SKU:
- CAB18108
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-DLL3 Antibody |
| Antibody SKU: | CAB18108 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-250 of human DLL3 (NP_058637.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-250 of human DLL3 (NP_058637.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AGVF ELQI HSFG PGPG PGAP RSPC SARL PCRL FFRV CLKP GLSE EAAE SPCA LGAA LSAR GPVY TEQP GAPA PDLP LPDG LLQV PFRD AWPG TFSF IIET WREE LGDQ IGGP AWSL LARV AGRR RLAA GGPW ARDI QRAG AWEL RFSY RARC EPPA VGTA CTRL CRPR SAPS RCGP GLRP CAPL EDEC EAPL VCRA GCSP EHGF CEQP GECR CLEG WTGP LCTV |
| Gene ID: | 10683 |
| Uniprot: | Q9NYJ7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | SCDO1, DLL3 |
| Background: |
| UniProt Protein Function: | DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13 Cellular Component: integral to membrane Molecular Function:Notch binding Biological Process: compartment specification; paraxial mesoderm development; Notch signaling pathway; somitogenesis; skeletal development; negative regulation of neurogenesis Disease: Spondylocostal Dysostosis 1, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NYJ7 |
| NCBI GenInfo Identifier: | 45243561 |
| NCBI Gene ID: | 10683 |
| NCBI Accession: | NP_982353.1 |
| UniProt Secondary Accession: | Q9NYJ7,Q8NBS4, E9PFG2, |
| UniProt Related Accession: | Q9NYJ7 |
| Molecular Weight: | |
| NCBI Full Name: | delta-like protein 3 isoform 2 |
| NCBI Synonym Full Names: | delta-like 3 (Drosophila) |
| NCBI Official Symbol: | DLL3 |
| NCBI Official Synonym Symbols: | SCDO1 |
| NCBI Protein Information: | delta-like protein 3; delta3; drosophila Delta homolog 3 |
| UniProt Protein Name: | Delta-like protein 3 |
| UniProt Synonym Protein Names: | Drosophila Delta homolog 3 |
| Protein Family: | Delta-like protein |
| UniProt Gene Name: | DLL3 |
| UniProt Entry Name: | DLL3_HUMAN |
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