Anti-DLL1 Antibody (CAB14277)
- SKU:
- CAB14277
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DLL1 Antibody |
| Antibody SKU: | CAB14277 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-723 of human DLL1 (NP_005609.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, Mouse brain, Mouse pancreas, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 573-723 of human DLL1 (NP_005609.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQKH RPPA DPCR GETE TMNN LANC QREK DISV SIIG ATQI KNTN KKAD FHGD HSAD KNGF KARY PAVD YNLV QDLK GDDT AVRD AHSK RDTK CQPQ GSSG EEKG TPTT LRGG EASE RKRP DSGC STSK DTKY QSVY VISE EKDE CVIA TEV |
| Gene ID: | 28514 |
| Uniprot: | O00548 |
| Cellular Location: | Apical cell membrane, Cell junction, Membrane raft, Single-pass type I membrane protein, adherens junction |
| Calculated MW: | 27kDa/78kDa |
| Observed MW: | 78kDa |
| Synonyms: | DLL1, DELTA1, DL1, Delta |
| Background: | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. |
| UniProt Protein Function: | DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell development/differentiation Chromosomal Location of Human Ortholog: 6q27 Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytoplasmic vesicle Molecular Function:protein binding; calcium ion binding; Notch binding Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; determination of left/right symmetry; cell differentiation; inner ear development; positive regulation of Notch signaling pathway |
| NCBI Summary: | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00548 |
| NCBI GenInfo Identifier: | 118582508 |
| NCBI Gene ID: | 28514 |
| NCBI Accession: | O00548.2 |
| UniProt Secondary Accession: | O00548,Q9NU41, Q9UJV2, B2RAK7, B5M0B3, |
| UniProt Related Accession: | O00548 |
| Molecular Weight: | 723 |
| NCBI Full Name: | Delta-like protein 1 |
| NCBI Synonym Full Names: | delta-like 1 (Drosophila) |
| NCBI Official Symbol: | DLL1 |
| NCBI Official Synonym Symbols: | DL1; Delta; DELTA1 |
| NCBI Protein Information: | delta-like protein 1; H-Delta-1; drosophila Delta homolog 1 |
| UniProt Protein Name: | Delta-like protein 1 |
| UniProt Synonym Protein Names: | Drosophila Delta homolog 1; Delta1; H-Delta-1 |
| Protein Family: | Delta-like protein |
| UniProt Gene Name: | DLL1 |
| UniProt Entry Name: | DLL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DLL1 antibody (CAB14277) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat pancreas using DLL1 antibody (CAB14277) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using DLL1 antibody (CAB14277) at dilution of 1:100 (40x lens). |
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