| UniProt Protein Function: | DKK3: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular space Biological Process: anatomical structure morphogenesis; Wnt receptor signaling pathway; adrenal gland development; negative regulation of aldosterone biosynthetic process; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBP4 |
| NCBI GenInfo Identifier: | 311033372 |
| NCBI Gene ID: | 27122 |
| NCBI Accession: | Q9UBP4.2 |
| UniProt Secondary Accession: | Q9UBP4,Q9ULB7, A8K1I2, D3DQW1, |
| UniProt Related Accession: | Q9UBP4 |
| Molecular Weight: | 38,390 Da |
| NCBI Full Name: | Dickkopf-related protein 3 |
| NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 3 |
| NCBI Official Symbol: | DKK3 |
| NCBI Official Synonym Symbols: | RIG; REIC |
| NCBI Protein Information: | dickkopf-related protein 3; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG-like 7-1; dickkopf 3 homolog; dickkopf homolog 3; regulated in glioma |
| UniProt Protein Name: | Dickkopf-related protein 3 |
| Protein Family: | Dickkopf-related protein |
| UniProt Gene Name: | DKK3 |
| UniProt Entry Name: | DKK3_HUMAN |
