Anti-DISP1 Antibody (CAB14946)
- SKU:
- CAB14946
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DISP1 Antibody |
| Antibody SKU: | CAB14946 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1325-1524 of human DISP1 (NP_116279.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1325-1524 of human DISP1 (NP_116279.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FVHP ITHI HHCP CLQG RVKP AGMQ NSLP RNFF LHPV QHIQ AQEK IGKT NVHS LQRS IEEH LPKM AEPS SFVC RSTG SLLK TCCD PENK QREL CKNR DVSN LESS GGTE NKAG GKVE LSLS QTDA SVNS EHFN QNEP KVLF NHLM GEAG CRSC PNNS QSCG RIVR VKCN SVDC QMPN MEAN VPAV LTHS ELSG ESLL IKTL |
| Gene ID: | 84976 |
| Uniprot: | Q96F81 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 170kDa |
| Observed MW: | 180kDa |
| Synonyms: | DISP1, DISPA |
| Background: | The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. |
| UniProt Protein Function: | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404). |
| NCBI Summary: | The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96F81 |
| NCBI GenInfo Identifier: | 25952134 |
| NCBI Gene ID: | 84976 |
| NCBI Accession: | NP_116279.2 |
| UniProt Secondary Accession: | Q96F81,Q8N7C2, Q96I92, Q9H698, Q9H8H9, Q9UFA2, |
| UniProt Related Accession: | Q96F81 |
| Molecular Weight: | 167 |
| NCBI Full Name: | protein dispatched homolog 1 isoform 1 |
| NCBI Synonym Full Names: | dispatched RND transporter family member 1 |
| NCBI Official Symbol: | DISP1 |
| NCBI Official Synonym Symbols: | DISPA |
| NCBI Protein Information: | protein dispatched homolog 1 |
| UniProt Protein Name: | Protein dispatched homolog 1 |
| Protein Family: | Protein dispatched |
| UniProt Gene Name: | DISP1 |
 | Western blot analysis of extracts of various cell lines, using DISP1 antibody (CAB14946) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-CHD1L Antibody (CAB17558)
Anti-ADAM19 Antibody (CAB10260)
