Anti-Decorin Antibody (CAB1669)
- SKU:
- CAB1669
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Decorin Antibody |
| Antibody SKU: | CAB1669 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-359 of human Decorin (NP_598010.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-359 of human Decorin (NP_598010.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DEAS GIGP EVPD DRDF EPSL GPVC PFRC QCHL RVVQ CSDL GLDK VPKD LPPD TTLL DLQN NKIT EIKD GDFK NLKN LHAL ILVN NKIS KVSP GAFT PLVK LERL YLSK NQLK ELPE KMPK TLQE LRAH ENEI TKVR KVTF NGLN QMIV IELG TNPL KSSG IENG AFQG MKKL SYIR IADT NITS IPQG LPPS LTEL HLDG NKIS RVDA ASLK GLNN LAKL GLSF NSIS AVDN GSLA NTPH LREL HLDN NKLT RVPG GLAE HKYI QVVY LHNN NISV VGSS DFCP PGHN TKKA SYSG VSLF SNPV QYWE IQPS TFRC VYVR SAIQ LGNY K |
| Gene ID: | 1634 |
| Uniprot: | P07585 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 8kDa/19kDa/23kDa/27kDa/39kDa |
| Observed MW: | 49kDa |
| Synonyms: | DCN, CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, Decorin |
| Background: | This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. |
| UniProt Protein Function: | DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Extracellular matrix; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q21.33 Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region; collagen type VI Molecular Function:collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; wound healing; response to lipopolysaccharide; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; chondroitin sulfate catabolic process; carbohydrate metabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development Disease: Corneal Dystrophy, Congenital Stromal |
| NCBI Summary: | The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07585 |
| NCBI GenInfo Identifier: | 129951 |
| NCBI Gene ID: | 1634 |
| NCBI Accession: | P07585.1 |
| UniProt Secondary Accession: | P07585,Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9, |
| UniProt Related Accession: | P07585 |
| Molecular Weight: | 8,266 Da |
| NCBI Full Name: | Decorin |
| NCBI Synonym Full Names: | decorin |
| NCBI Official Symbol: | DCN |
| NCBI Official Synonym Symbols: | CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B |
| NCBI Protein Information: | decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II |
| UniProt Protein Name: | Decorin |
| UniProt Synonym Protein Names: | Bone proteoglycan II; PG-S2; PG40 |
| Protein Family: | Decorin |
| UniProt Gene Name: | DCN |
| UniProt Entry Name: | PGS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Decorin antibody (CAB1669) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat lung using Decorin antibody (CAB1669) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using Decorin antibody (CAB1669) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using Decorin antibody (CAB1669). Blue: DAPI for nuclear staining. |
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