Anti-DCXR Antibody (CAB4721)

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SKU:
CAB4721
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DCXR
DCR
HCR2
HCRII
KIDCR
P34H
PNTSU
SDR20C1
XR
Frequently bought together:

Description

Product Name:DCXR Rabbit pAb
Product Code:CAB4721
Size:20uL, 50uL, 100uL
Synonyms:DCXR, DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human DCXR (NP_057370.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, MCF7, NCI-H460, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human DCXR (NP_057370.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MELF LAGR RVLV TGAG KGIG RGTV QALH ATGA RVVA VSRT QADL DSLV RECP GIEP VCVD LGDW EATE RALG SVGP VDLL VNNA AVAL LQPF LEVT KEAF DRSF EVNL RAVI QVSQ IVAR GLIA RGVP GAIV NVSS QCSQ RAVT NHSV YCST KGAL DMLT KVMA LELG PHKI RVNA VNPT VVMT SMGQ ATWS DPHK AKTM LNRI PLGK FAEV EHVV NAIL FLLS DRSG MTTG STLP VEGG FWAC
Gene ID:51181
Uniprot:Q7Z4W1
Cellular Location:Membrane, Peripheral membrane protein
Calculated MW:25kDa
Observed MW:31kDa
UniProt Protein Function:DCXR: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
UniProt Protein Details:

Protein type:Oxidoreductase; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 1.1.1.10

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: microvillus; membrane; cytoplasmic microtubule; nucleus; brush border

Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; L-xylulose reductase activity

Biological Process: glucose metabolic process; xylulose metabolic process; D-xylose metabolic process; NADP metabolic process; protein homotetramerization

Disease: Pentosuria

NCBI Summary:The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
UniProt Code:Q7Z4W1
NCBI GenInfo Identifier:50400451
NCBI Gene ID:51181
NCBI Accession:Q7Z4W1.2
UniProt Related Accession:Q7Z4W1
Molecular Weight:
NCBI Full Name:L-xylulose reductase
NCBI Synonym Full Names:dicarbonyl and L-xylulose reductase
NCBI Official Symbol:DCXR  
NCBI Official Synonym Symbols:XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1  
NCBI Protein Information:L-xylulose reductase
UniProt Protein Name:L-xylulose reductase
UniProt Synonym Protein Names:Carbonyl reductase II; Dicarbonyl/L-xylulose reductase; Kidney dicarbonyl reductase; kiDCR; Sperm surface protein P34H
UniProt Gene Name:DCXR  
UniProt Entry Name:DCXR_HUMAN

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