Anti-DCSTAMP Antibody (CAB14630)
- SKU:
- CAB14630
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DCSTAMP Antibody |
| Antibody SKU: | CAB14630 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-470 of human DCSTAMP (NP_110415.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KILV SASF YPSV ERKR IQYL HAKL LKKR SKQP LGEV KRRL SLYL TKIH FWLP VLKM IRKK QMDM ASAD KS |
| Gene ID: | 81501 |
| Uniprot: | Q9H295 |
| Cellular Location: | Cell membrane, Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Endosome, Multi-pass membrane protein |
| Calculated MW: | 31kDa/53kDa |
| Observed MW: | 53kDa |
| Synonyms: | DCSTAMP, FIND, TM7SF4, hDC-STAMP |
| Background: | This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | Tm7sf4: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8q23 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; cell surface; integral to plasma membrane; integral to membrane; integral to endoplasmic reticulum membrane; endosome membrane Molecular Function:protein binding Biological Process: positive regulation of monocyte differentiation; positive regulation of bone resorption; myeloid dendritic cell differentiation; osteoclast differentiation; negative regulation of cell growth |
| NCBI Summary: | This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q9H295 |
| NCBI GenInfo Identifier: | 119612298 |
| NCBI Gene ID: | 81501 |
| NCBI Accession: | EAW91892.1 |
| UniProt Secondary Accession: | Q9H295,Q2M2D5, B7ZVW2, E7ESG0, |
| UniProt Related Accession: | Q9H295 |
| Molecular Weight: | 31,586 Da |
| NCBI Full Name: | transmembrane 7 superfamily member 4 |
| NCBI Synonym Full Names: | dendrocyte expressed seven transmembrane protein |
| NCBI Official Symbol: | DCSTAMP |
| NCBI Official Synonym Symbols: | FIND; TM7SF4; hDC-STAMP |
| NCBI Protein Information: | dendritic cell-specific transmembrane protein |
| UniProt Protein Name: | Dendritic cell-specific transmembrane protein |
| UniProt Synonym Protein Names: | Dendrocyte-expressed seven transmembrane protein; IL-four-induced protein; FIND; Transmembrane 7 superfamily member 4 |
| UniProt Gene Name: | DCSTAMP |
| UniProt Entry Name: | DCSTP_HUMAN |
 | Western blot analysis of extracts of 293T cells, using DCSTAMP antibody (CAB14630) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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