Anti-DCP1A Antibody (CAB6824)
- SKU:
- CAB6824
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-DCP1A Antibody |
| Antibody SKU: | CAB6824 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human DCP1A |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, HepG2, SH-SY5Y |
| Immunogen: | A synthesized peptide derived from human DCP1A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55802 |
| Uniprot: | Q9NPI6 |
| Cellular Location: | |
| Calculated MW: | 75kDa |
| Observed MW: | 73KDa |
| Synonyms: | HSA275986, Nbla00360, SMAD4IP1, SMIF |
| Background: | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Protein Function: | DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling. |
| UniProt Protein Details: | Protein type:RNA processing; Transcription, coactivator/corepressor; EC 3.-.-.-; Hydrolase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: cytosol; intracellular membrane-bound organelle; membrane; nucleus Molecular Function:enzyme activator activity; enzyme regulator activity; hydrolase activity; identical protein binding; mRNA binding; protein binding Biological Process: deadenylation-dependent decapping; deadenylation-independent decapping; gene expression; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; regulation of mRNA stability |
| NCBI Summary: | Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9NPI6 |
| NCBI GenInfo Identifier: | 296434475 |
| NCBI Gene ID: | 55802 |
| NCBI Accession: | Q9NPI6.2 |
| UniProt Secondary Accession: | Q9NPI6,B4DHN9, U3KQM8, |
| UniProt Related Accession: | Q9NPI6 |
| Molecular Weight: | 59,361 Da |
| NCBI Full Name: | mRNA-decapping enzyme 1A |
| NCBI Synonym Full Names: | decapping mRNA 1A |
| NCBI Official Symbol: | DCP1A |
| NCBI Official Synonym Symbols: | SMIF; SMAD4IP1; HSA275986; Nbla00360 |
| NCBI Protein Information: | mRNA-decapping enzyme 1A |
| UniProt Protein Name: | mRNA-decapping enzyme 1A |
| UniProt Synonym Protein Names: | Smad4-interacting transcriptional co-activator; Transcription factor SMIF |
| Protein Family: | mRNA-decapping enzyme |
| UniProt Gene Name: | DCP1A |
| UniProt Entry Name: | DCP1A_HUMAN |
 | Western blot - DCP1A Rabbit mAb (CAB6824) |
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