Anti-DAPK2 Antibody (CAB8199)
- SKU:
- CAB8199
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | DAPK2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8199 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human DAPK2 (NP_055141.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human DAPK2 (NP_055141.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VVNL ENFR KQYV RRRW KLSF SIVS LCNH LTRS LMKK VHLR PDED LRNC ESDT EEDI ARRK ALHP RRRS STS |
| Gene ID: | 23604 |
| Uniprot: | Q9UIK4 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, autophagosome lumen |
| Calculated MW: | 42kDa/55kDa |
| Observed MW: | Refer to figures |
| Synonyms: | DAPK2, DRP-1, DRP1 |
| Background: | This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. |
| UniProt Protein Function: | DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle. |
| UniProt Protein Details: | Protein type:Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; CAMK group; DAPK family Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytoplasm Molecular Function:ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity Biological Process: anoikis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy |
| NCBI Summary: | This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UIK4 |
| NCBI GenInfo Identifier: | 38605084 |
| NCBI Gene ID: | 23604 |
| NCBI Accession: | Q9UIK4.1 |
| UniProt Secondary Accession: | Q9UIK4,O75892, Q24JS1, E9JGM7, |
| UniProt Related Accession: | Q9UIK4 |
| Molecular Weight: | 55,931 Da |
| NCBI Full Name: | Death-associated protein kinase 2 |
| NCBI Synonym Full Names: | death associated protein kinase 2 |
| NCBI Official Symbol: | DAPK2 |
| NCBI Official Synonym Symbols: | DRP1; DRP-1 |
| NCBI Protein Information: | death-associated protein kinase 2 |
| UniProt Protein Name: | Death-associated protein kinase 2 |
| UniProt Synonym Protein Names: | DAP-kinase-related protein 1; DRP-1 |
| Protein Family: | Death-associated protein kinase |
| UniProt Gene Name: | DAPK2 |
| UniProt Entry Name: | DAPK2_HUMAN |
 | Immunofluorescence analysis of U2OS cells using DAPK2 antibody (CAB8199) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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