| UniProt Protein Function: | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. |
| NCBI Summary: | Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P53355 |
| NCBI GenInfo Identifier: | 317373595 |
| NCBI Gene ID: | 1612 |
| NCBI Accession: | P53355.6 |
| UniProt Secondary Accession: | P53355,Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8, B7ZLD2 B7ZLE7, |
| UniProt Related Accession: | P53355 |
| Molecular Weight: | 152,467 Da |
| NCBI Full Name: | Death-associated protein kinase 1 |
| NCBI Synonym Full Names: | death associated protein kinase 1 |
| NCBI Official Symbol: | DAPK1 |
| NCBI Official Synonym Symbols: | DAPK |
| NCBI Protein Information: | death-associated protein kinase 1 |
| UniProt Protein Name: | Death-associated protein kinase 1 |
| Protein Family: | Death-associated protein kinase |
| UniProt Gene Name: | DAPK1 |
| UniProt Entry Name: | DAPK1_HUMAN |
