Anti-DAB1 Antibody (CAB10349)
- SKU:
- CAB10349
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-DAB1 Antibody |
| Antibody SKU: | CAB10349 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DAB1 (NP_066566.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, Mouse brain, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-185 of human DAB1 (NP_066566.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSTE TELQ VAVK TSAK KDSR KKGQ DRSE ATLI KRFK GEGV RYKA KLIG IDEV SAAR GDKL CQDS MMKL KGVV AGAR SKGE HKQK IFLT ISFG GIKI FDEK TGAL QHHH AVHE ISYI AKDI TDHR AFGY VCGK EGNH RFVA IKTA QAAE PVIL DLRD LFQL IYEL KQRE ELEK KAQK DKQC EQAV Y |
| Gene ID: | 1600 |
| Uniprot: | O75553 |
| Cellular Location: | |
| Calculated MW: | 24kDa/49kDa/57kDa/59kDa/63kDa |
| Observed MW: | 63kDa |
| Synonyms: | DAB1, SCA37 |
| Background: | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. |
| UniProt Protein Function: | DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1p32.2 Cellular Component: cytosol; intracellular membrane-bound organelle Molecular Function:protein binding |
| NCBI Summary: | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017] |
| UniProt Code: | O75553 |
| NCBI GenInfo Identifier: | 150421536 |
| NCBI Gene ID: | 1600 |
| NCBI Accession: | O75553.3 |
| UniProt Secondary Accession: | O75553,Q4LE59, Q5T6M6, Q5T6M9, Q5T835, Q5T836, Q5T837 Q6NWS9, Q6NWT0, Q6NWT1, A4FU90, B3KTG3, |
| UniProt Related Accession: | O75553 |
| Molecular Weight: | 64kDa |
| NCBI Full Name: | Disabled homolog 1 |
| NCBI Synonym Full Names: | DAB1, reelin adaptor protein |
| NCBI Official Symbol: | DAB1 |
| NCBI Protein Information: | disabled homolog 1 |
| UniProt Protein Name: | Disabled homolog 1 |
| Protein Family: | Disabled |
| UniProt Gene Name: | DAB1 |
 | Western blot analysis of extracts of various cell lines, using DAB1 antibody (CAB10349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of SH-SY5Y cells using DAB1 Rabbit pAb (CAB10349) at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining. |
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