Anti-Cytokeratin 12 (KRT12) Antibody (CAB19284)
- SKU:
- CAB19284
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KRT12
- K12
- keratin 12
Frequently bought together:
Description
| Product Name: | Cytokeratin 12 (KRT12) Rabbit mAb |
| Product Code: | CAB19284 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | KRT12, K12, keratin 12 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Cytokeratin 12 (KRT12) (KRT12). |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat eye |
| Immunogen: | Recombinant protein of human Cytokeratin 12 (KRT12) (KRT12). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3859 |
| Uniprot: | Q99456 |
| Calculated MW: | 54kDa |
| Observed MW: | 54KDa |
| UniProt Protein Function: | K12: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q12 Biological Process: visual perception Disease: Corneal Dystrophy, Meesmann |
| NCBI Summary: | KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99456 |
| NCBI GenInfo Identifier: | 2497269 |
| NCBI Gene ID: | 3859 |
| NCBI Accession: | Q99456.1 |
| UniProt Secondary Accession: | Q99456,B2R9E0, |
| UniProt Related Accession: | Q99456 |
| Molecular Weight: | 53,511 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 12 |
| NCBI Synonym Full Names: | keratin 12 |
| NCBI Official Symbol: | KRT12 |
| NCBI Official Synonym Symbols: | K12 |
| NCBI Protein Information: | keratin, type I cytoskeletal 12 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 12 |
| UniProt Synonym Protein Names: | Cytokeratin-12; CK-12; Keratin-12; K12 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT12 |
| UniProt Entry Name: | K1C12_HUMAN |
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