Anti-Cytokeratin 1 (KRT1) Antibody (CAB9776)

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SKU:
CAB9776
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CK1
Synonyms:
EHK
Synonyms:
EHK1
Synonyms:
EPPK
Synonyms:
K1
Synonyms:
KRT1A
Synonyms:
NEPPK
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Description

Product Name:Cytokeratin 1 (KRT1) Rabbit mAb
Product Code:CAB9776
Size:20uL, 50uL, 100uL
Synonyms:CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytokeratin 1 (KRT1) (KRT1)
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain, A375
Immunogen:A synthesized peptide derived from human Cytokeratin 1 (KRT1) (KRT1)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3848
Uniprot:P04264
Cellular Location:Cell membrane
Calculated MW:66kDa
Observed MW:70kDa
UniProt Protein Function:K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoskeleton; extracellular matrix; extracellular space; membrane; nucleus

Molecular Function:carbohydrate binding; protein binding

Biological Process: complement activation, lectin pathway; retinal homeostasis

Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic

NCBI Summary:The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Code:P04264
NCBI GenInfo Identifier:238054406
NCBI Gene ID:3848
NCBI Accession:P04264.6
UniProt Secondary Accession:P04264,P85925, P86104, Q14720, Q6GSJ0, Q9H298, B2RA01
UniProt Related Accession:P04264
Molecular Weight:66,039 Da
NCBI Full Name:Keratin, type II cytoskeletal 1
NCBI Synonym Full Names:keratin 1
NCBI Official Symbol:KRT1  
NCBI Official Synonym Symbols:K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK  
NCBI Protein Information:keratin, type II cytoskeletal 1
UniProt Protein Name:Keratin, type II cytoskeletal 1
UniProt Synonym Protein Names:67 kDa cytokeratin; Cytokeratin-1; CK-1; Hair alpha protein; Keratin-1; K1; Type-II keratin Kb1
Protein Family:Keratin
UniProt Gene Name:KRT1  
UniProt Entry Name:K2C1_HUMAN
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