Anti-Cytochrome P450 4A (CYP4A11) Antibody (CAB19662)

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SKU:
CAB19662
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CP4Y
CYP4A2
CYP4AII
Frequently bought together:

Description

Product Name:Cytochrome P450 4A (CYP4A11) Rabbit mAb
Product Code:CAB19662
Size:20uL, 50uL, 100uL
Synonyms:CP4Y, CYP4A2, CYP4AII
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Cytochrome P450 4A (CYP4A11) (CYP4A11)
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human Cytochrome P450 4A (CYP4A11) (CYP4A11)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1579
Uniprot:Q02928
Calculated MW:50kDa
Observed MW:59KDa
UniProt Protein Function:CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - fatty acid; Lipid Metabolism - arachidonic acid; EC 1.14.15.3; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm

Molecular Function:leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity

Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; leukotriene metabolic process; sodium ion homeostasis; epoxygenase P450 pathway; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
UniProt Code:Q02928
NCBI GenInfo Identifier:2493371
NCBI Gene ID:1579
NCBI Accession:Q02928.1
UniProt Secondary Accession:Q02928,Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5
UniProt Related Accession:Q02928
Molecular Weight:519
NCBI Full Name:Cytochrome P450 4A11
NCBI Synonym Full Names:cytochrome P450, family 4, subfamily A, polypeptide 11
NCBI Official Symbol:CYP4A11  
NCBI Official Synonym Symbols:CP4Y; CYP4A2; CYP4AII  
NCBI Protein Information:cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11
UniProt Protein Name:Cytochrome P450 4A11
UniProt Synonym Protein Names:20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3)
Protein Family:Cytochrome
UniProt Gene Name:CYP4A11  
UniProt Entry Name:CP4AB_HUMAN

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