Anti-CYP51A1 Antibody (CAB6252)
- SKU:
- CAB6252
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CYP51A1 Antibody |
| Antibody SKU: | CAB6252 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human CYP51A1 (NP_000777.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human CYP51A1 (NP_000777.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTAS HCLH GKEI RSQL NEKV AQLY ADLD GGFS HAAW LLPG WLPL PSFR RRDR AHRE IKDI FYKA IQKR RQSQ EKID DILQ TLLD ATYK DGRP LTDD EVAG MLIG LLLA GQHT SSTT SAWM GFFL ARDK TLQK KCYL EQKT VCGE NLPP LTYD QLKD LNLL DRCI KETL RLRP PIMI MMRM ARTP QTVA GYTI PPGH QVCV SPTV NQRL KDSW VERL DFNP DRYL QDNP ASGE KFAY VPFG AGRH RCIG ENFA YVQI KTIW STML RLYE FDLI DGYF PTVN YTTM IHTP ENPV IRYK RRSK |
| Gene ID: | 1595 |
| Uniprot: | Q16850 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane |
| Calculated MW: | 46kDa/56kDa |
| Observed MW: | 63kDa |
| Synonyms: | CYP51A1, CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1, CYP51A1 |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.14.13.70; Membrane protein, integral; Lipid Metabolism - steroid biosynthesis Chromosomal Location of Human Ortholog: 7q21.2 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:sterol 14-demethylase activity; iron ion binding; heme binding Biological Process: xenobiotic metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; sterol metabolic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q16850 |
| NCBI GenInfo Identifier: | 3915660 |
| NCBI Gene ID: | 1595 |
| NCBI Accession: | Q16850.3 |
| UniProt Secondary Accession: | Q16850,O00770, O00772, Q16784, Q8N1A8, Q99868, A4D1F8 B2RAI4, B4DJ55, |
| UniProt Related Accession: | Q16850 |
| Molecular Weight: | 503 |
| NCBI Full Name: | Lanosterol 14-alpha demethylase |
| NCBI Synonym Full Names: | cytochrome P450, family 51, subfamily A, polypeptide 1 |
| NCBI Official Symbol: | CYP51A1 |
| NCBI Official Synonym Symbols: | LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM |
| NCBI Protein Information: | lanosterol 14-alpha demethylase; CYPLI; cytochrome P450LI; cytochrome P45014DM; cytochrome P450 51A1; cytochrome P450-14DM; lanosterol 14-alpha-demethylase; cytochrome P450, 51 (lanosterol 14-alpha-demethylase) |
| UniProt Protein Name: | Lanosterol 14-alpha demethylase |
| UniProt Synonym Protein Names: | CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase |
| UniProt Gene Name: | CYP51A1 |
| UniProt Entry Name: | CP51A_HUMAN |
Related Products
Anti-CYP51A1 Antibody (CAB13485)
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
Anti-VASH1 Antibody (CAB12569)
