| UniProt Protein Function: | CYP4F2: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.30; EC 1.14.13.194; Oxidoreductase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm Molecular Function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; leukotriene-B4 20-monooxygenase activity; protein binding; iron ion binding; heme binding; arachidonic acid epoxygenase activity; vitamin-K-epoxide reductase (warfarin-sensitive) activity; alkane 1-monooxygenase activity Biological Process: negative regulation of icosanoid secretion; icosanoid metabolic process; negative regulation of blood coagulation; vitamin K catabolic process; leukotriene metabolic process; epoxygenase P450 pathway; long-chain fatty acid metabolic process; phylloquinone catabolic process; vitamin E metabolic process; vitamin K biosynthetic process; very-long-chain fatty acid metabolic process; menaquinone catabolic process; xenobiotic metabolic process; regulation of blood pressure; positive regulation of icosanoid secretion; arachidonic acid metabolic process; renal water homeostasis; sodium ion homeostasis; drug metabolic process; blood coagulation; pressure natriuresis |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78329 |
| NCBI GenInfo Identifier: | 13435391 |
| NCBI Gene ID: | 8529 |
| NCBI Accession: | NP_001073.3 |
| UniProt Secondary Accession: | P78329,Q16677, Q6NWT4, Q6NWT6, Q9NNZ0, Q9UIU8, A0A024R7K3 A8K425, B4DV75, |
| UniProt Related Accession: | P78329 |
| Molecular Weight: | 21,709 Da |
| NCBI Full Name: | phylloquinone omega-hydroxylase CYP4F2 |
| NCBI Synonym Full Names: | cytochrome P450, family 4, subfamily F, polypeptide 2 |
| NCBI Official Symbol: | CYP4F2 |
| NCBI Official Synonym Symbols: | CPF2 |
| NCBI Protein Information: | phylloquinone omega-hydroxylase CYP4F2; CYPIVF2; 20-HETE synthase; cytochrome P450 4F2; cytochrome P450-LTB-omega; arachidonic acid omega-hydroxylase; leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVF, polypeptide 2 |
| UniProt Protein Name: | Phylloquinone omega-hydroxylase CYP4F2 |
| UniProt Synonym Protein Names: | 20-hydroxyeicosatetraenoic acid synthase; Arachidonic acid omega-hydroxylase; CYPIVF2 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP4F2 |
| UniProt Entry Name: | CP4F2_HUMAN |
