Anti-CYP3A5 Antibody (CAB7663)
- SKU:
- CAB7663
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CYP3A5 Antibody |
| Antibody SKU: | CAB7663 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 233-502 of human CYP3A5 (NP_000768.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 233-502 of human CYP3A5 (NP_000768.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FEAL NVSL FPKD TINF LSKS VNRM KKSR LNDK QKHR LDFL QLMI DSQN SKET ESHK ALSD LELA AQSI IFIF AGYE TTSS VLSF TLYE LATH PDVQ QKLQ KEID AVLP NKAP PTYD AVVQ MEYL DMVV NETL RLFP VAIR LERT CKKD VEIN GVFI PKGS MVVI PTYA LHHD PKYW TEPE EFRP ERFS KKKD SIDP YIYT PFGT GPRN CIGM RFAL MNMK LALI RVLQ NFSF KPCK ETQI PLKL DTQG LLQP EKPI VLKV DSRD GTLS GE |
| Gene ID: | 1577 |
| Uniprot: | P20815 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 15kDa/57kDa |
| Observed MW: | 57kDa |
| Synonyms: | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CYP3A5: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.14.14.1; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:monooxygenase activity; oxidoreductase activity; oxygen binding Biological Process: alkaloid catabolic process; drug catabolic process; steroid metabolic process; xenobiotic metabolic process Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P20815 |
| NCBI GenInfo Identifier: | 117157 |
| NCBI Gene ID: | 1577 |
| NCBI Accession: | P20815.1 |
| UniProt Secondary Accession: | P20815,Q53WY8, Q75MV0, Q9HB56, A4D289, B7Z5I7, |
| UniProt Related Accession: | P20815 |
| Molecular Weight: | 15,846 Da |
| NCBI Full Name: | Cytochrome P450 3A5 |
| NCBI Synonym Full Names: | cytochrome P450 family 3 subfamily A member 5 |
| NCBI Official Symbol: | CYP3A5 |
| NCBI Official Synonym Symbols: | CP35; PCN3; CYPIIIA5; P450PCN3 |
| NCBI Protein Information: | cytochrome P450 3A5 |
| UniProt Protein Name: | Cytochrome P450 3A5 |
| UniProt Synonym Protein Names: | CYPIIIA5; Cytochrome P450 HLp2; Cytochrome P450-PCN3 |
| UniProt Gene Name: | CYP3A5 |
| UniProt Entry Name: | CP3A5_HUMAN |
 | Western blot analysis of extracts of Rat thymus, using CYP3A5 antibody (CAB7663) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
Related Products
Human CYP3A5 / Cytochrome P450 3A5 ELISA Kit
