Anti-CYP2J2 Antibody (CAB5805)
- SKU:
- CAB5805
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CYP2J2 Antibody |
| Antibody SKU: | CAB5805 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP2J2 (NP_000766.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP2J2 (NP_000766.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RFEY QDSW FQQL LKLL DEVT YLEA SKTC QLYN VFPW IMKF LPGP HQTL FSNW KKLK LFVS HMID KHRK DWNP AETR DFID AYLK EMSK HTGN PTSS FHEE N |
| Gene ID: | 1573 |
| Uniprot: | P51589 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| Synonyms: | CYP2J2, CPJ2, CYPIIJ2 |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. |
| UniProt Protein Function: | CYP2J2: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:EC 1.14.14.1; Contractile; Oxidoreductase; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 1p31.3-p31.2 Cellular Component: endoplasmic reticulum membrane Molecular Function:arachidonic acid 11,12-epoxygenase activity; arachidonic acid 14,15-epoxygenase activity; arachidonic acid epoxygenase activity; monooxygenase activity; steroid hydroxylase activity Biological Process: epoxygenase P450 pathway; icosanoid metabolic process; linoleic acid metabolic process; regulation of heart contraction; xenobiotic metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P51589 |
| NCBI GenInfo Identifier: | 21264413 |
| NCBI Gene ID: | 1573 |
| NCBI Accession: | P51589.2 |
| UniProt Secondary Accession: | P51589,Q8TF13, B2RD33, |
| UniProt Related Accession: | P51589 |
| Molecular Weight: | 57,611 Da |
| NCBI Full Name: | Cytochrome P450 2J2 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily J member 2 |
| NCBI Official Symbol: | CYP2J2 |
| NCBI Official Synonym Symbols: | CPJ2; CYPIIJ2 |
| NCBI Protein Information: | cytochrome P450 2J2 |
| UniProt Protein Name: | Cytochrome P450 2J2 |
| UniProt Synonym Protein Names: | Arachidonic acid epoxygenase; CYPIIJ2 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2J2 |
| UniProt Entry Name: | CP2J2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYP2J2 Antibody (CAB5805) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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