Anti-CYC1 Antibody (CAB10449)
- SKU:
- CAB10449
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CYC1 Antibody |
| Antibody SKU: | CAB10449 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 85-291 of human CYC1 (NP_001907.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, A375, LO2, 22Rv1, Mouse brain, Mouse kidney, Mouse liver, Mouse heart, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 85-291 of human CYC1 (NP_001907.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDLE LHPP SYPW SHRG LLSS LDHT SIRR GFQV YKQV CASC HSMD FVAY RHLV GVCY TEDE AKEL AAEV EVQD GPNE DGEM FMRP GKLF DYFP KPYP NSEA ARAA NNGA LPPD LSYI VRAR HGGE DYVF SLLT GYCE PPTG VSLR EGLY FNPY FPGQ AIAM APPI YTDV LEFD DGTP ATMS QIAK DVCT FLRW ASEP EHDH RKRM GLK |
| Gene ID: | 1537 |
| Uniprot: | P08574 |
| Cellular Location: | Intermembrane side, Mitochondrion inner membrane, Single-pass membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 35kDa |
| Synonyms: | CYC1, MC3DN6, UQCR4 |
| Background: | This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. |
| UniProt Protein Function: | CYC1: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. Belongs to the cytochrome c family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: membrane; mitochondrial inner membrane; mitochondrion; nucleus Molecular Function:electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Biological Process: mitochondrial electron transport, ubiquinol to cytochrome c Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 6 |
| NCBI Summary: | This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P08574 |
| NCBI GenInfo Identifier: | 311033458 |
| NCBI Gene ID: | 1537 |
| NCBI Accession: | P08574.3 |
| UniProt Secondary Accession: | P08574,Q5U062, Q6FHS7, |
| UniProt Related Accession: | P08574 |
| Molecular Weight: | 35,422 Da |
| NCBI Full Name: | Cytochrome c1, heme protein, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c1 |
| NCBI Official Symbol: | CYC1 |
| NCBI Official Synonym Symbols: | UQCR4; MC3DN6 |
| NCBI Protein Information: | cytochrome c1, heme protein, mitochondrial |
| UniProt Protein Name: | Cytochrome c1, heme protein, mitochondrial |
| UniProt Synonym Protein Names: | Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit; Cytochrome c-1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYC1 |
| UniProt Entry Name: | CY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CYC1 antibody (CAB10449) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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