Anti-CXCL4/PF4 Antibody (CAB3694)
- SKU:
- CAB3694
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CXCL4
- PF-4
- SCYB4
Description
| Product Name: | CXCL4/PF4 Rabbit mAb |
| Product Code: | CAB3694 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CXCL4, PF-4, SCYB4 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CXCL4/CXCL4/PF4 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human plasma, Mouse spleen |
| Immunogen: | A synthesized peptide derived from human CXCL4/CXCL4/PF4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5196 |
| Uniprot: | P02776 |
| Calculated MW: | 11kDa |
| Observed MW: | 11kDa |
| UniProt Protein Function: | PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Apoptosis; Secreted, signal peptide; Chemokine; Secreted Chromosomal Location of Human Ortholog: 4q12-q21 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; CXCR3 chemokine receptor binding; chemokine activity Biological Process: negative regulation of cytolysis; platelet activation; leukocyte chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; platelet degranulation; negative regulation of MHC class II biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of macrophage differentiation; inflammatory response; blood coagulation |
| NCBI Summary: | This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P02776 |
| NCBI GenInfo Identifier: | 130304 |
| NCBI Gene ID: | 5196 |
| NCBI Accession: | P02776.2 |
| UniProt Secondary Accession: | P02776,Q53X61, Q9UC64, Q9UC65, |
| UniProt Related Accession: | P02776 |
| Molecular Weight: | 10,845 Da |
| NCBI Full Name: | Platelet factor 4 |
| NCBI Synonym Full Names: | platelet factor 4 |
| NCBI Official Symbol: | PF4 |
| NCBI Official Synonym Symbols: | PF-4; CXCL4; SCYB4 |
| NCBI Protein Information: | platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4 |
| UniProt Protein Name: | Platelet factor 4 |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 4; Iroplact; Oncostatin-ACleaved into the following chain:Platelet factor 4, short form |
| Protein Family: | Platelet factor |
| UniProt Gene Name: | PF4 |
| UniProt Entry Name: | PLF4_HUMAN |
Related Products
Rat CXCL4 / PF4 ELISA Kit
Human CXCL4 / PF4 ELISA Kit
Mouse CXCL4 / PF4 ELISA Kit
