Anti-Cullin 1 Antibody (CAB19034)
- SKU:
- CAB19034
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Cullin 1 Antibody |
| Antibody SKU: | CAB19034 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cullin 1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, K-562, MCF7, NIH/3T3, Mouse liver, Mouse brain, Rat testis |
| Immunogen: | A synthesized peptide derived from human Cullin 1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8454 |
| Uniprot: | Q13616 |
| Cellular Location: | |
| Calculated MW: | 90kDa |
| Observed MW: | 90kDa |
 | Western blot - Cullin 1 Rabbit mAb (CAB19034) |
| Synonyms: | Cullin 1, CUL1, cullin-1, MGC149834, MGC149835 |
| Background: |
| UniProt Protein Function: | CUL1: a core scaffolding component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. The cullin subunit serves as a rigid scaffold of SCF complexes. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex depends on the neddylation of the cullin subunit. Interacts with multiple F-box proteins in SCF complexes, directing the ubiquitination of many substrates. These F-box proteins and associated substrates include: BTRC and FBXW11 bind CTNNB1 and participate in Wnt signaling; FBXW11 bind phosphorylated NFKBIA; BTRC binds NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2; SKP2 binds phosphorylated p27kip and is involved in regulation of G1/S transition; SKP2 binds ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1; FBXW7 binds cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1; FBXW2 binds GCM1; FBXO32 binds MYOD1; FBXO7 binds BIRC2 and DLGAP5; FBXO33 binds YBX1; and Cyclin F binds CP110. Interacts with CHEK2, mediating its ubiquitination and regulating its function. Belongs to the cullin family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Cell cycle regulation Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: nucleoplasm; cullin-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: protein monoubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; viral reproduction; protein ubiquitination; negative regulation of cell proliferation; cell proliferation; organ morphogenesis; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; cell cycle arrest; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle |
| UniProt Code: | Q13616 |
| NCBI GenInfo Identifier: | 19863257 |
| NCBI Gene ID: | 8454 |
| NCBI Accession: | Q13616.2 |
| UniProt Secondary Accession: | Q13616,O60719, Q08AL6, Q8IYW1, D3DWG3, |
| UniProt Related Accession: | Q13616 |
| Molecular Weight: | 89,679 Da |
| NCBI Full Name: | Cullin-1 |
| NCBI Synonym Full Names: | cullin 1 |
| NCBI Official Symbol: | CUL1 |
| NCBI Protein Information: | cullin-1; CUL-1 |
| UniProt Protein Name: | Cullin-1 |
| Protein Family: | Cullin |
| UniProt Gene Name: | CUL1 |
| UniProt Entry Name: | CUL1_HUMAN |
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