Anti-CTSS Antibody (CAB13482)
- SKU:
- CAB13482
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-CTSS Antibody |
| Antibody SKU: | CAB13482 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPDS VDWR EKGC VTEV KYQG SCGA CWAF SAVG ALEA QLKL KTGK LVSL SAQN LVDC STEK YGNK GCNG GFMT TAFQ YIID NKGI DSDA SYPY KAMD QKCQ YDSK YRAA TCSK YTEL PYGR EDVL KEAV ANKG PVSV GVDA RHPS FFLY RSGV YYEP SCTQ NVNH GVLV VGYG DLNG KEYW LVKN SWGH NFGE EGYI RMAR NKGN HCGI ASFP SYPE I |
| Gene ID: | 1520 |
| Uniprot: | P25774 |
| Cellular Location: | Lysosome |
| Calculated MW: | 31kDa/37kDa |
| Observed MW: |
| Synonyms: | CTSS |
| Background: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.22.27 Chromosomal Location of Human Ortholog: 1q21 Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle; lysosomal lumen; lysosome Molecular Function:collagen binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding; proteoglycan binding; serine-type endopeptidase activity Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; collagen catabolic process; extracellular matrix disassembly; immune response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; response to acidity; toll-like receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P25774 |
| NCBI GenInfo Identifier: | 88984046 |
| NCBI Gene ID: | 1520 |
| NCBI Accession: | P25774.3 |
| UniProt Secondary Accession: | P25774,Q5T5I0, Q6FHS5, Q9BUG3, B4DWC9, D3DV05, |
| UniProt Related Accession: | P25774 |
| Molecular Weight: | 31,626 Da |
| NCBI Full Name: | Cathepsin S |
| NCBI Synonym Full Names: | cathepsin S |
| NCBI Official Symbol: | CTSS |
| NCBI Protein Information: | cathepsin S |
| UniProt Protein Name: | Cathepsin S |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSS |
| UniProt Entry Name: | CATS_HUMAN |
 | Immunohistochemistry of paraffin-embedded human mammary gland using CTSS antibody (CAB13482) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using CTSS antibody (CAB13482) at dilution of 1:200 (40x lens). |
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