Anti-CTSL Antibody (CAB12200)
- SKU:
- CAB12200
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CTSL Antibody |
| Antibody SKU: | CAB12200 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human CTSL (NP_001903.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, 293T, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 114-333 of human CTSL (NP_001903.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APRS VDWR EKGY VTPV KNQG QCGS CWAF SATG ALEG QMFR KTGR LISL SEQN LVDC SGPQ GNEG CNGG LMDY AFQY VQDN GGLD SEES YPYE ATEE SCKY NPKY SVAN DTGF VDIP KQEK ALMK AVAT VGPI SVAI DAGH ESFL FYKE GIYF EPDC SSED MDHG VLVV GYGF ESTE SDNN KYWL VKNS WGEE WGMG GYVK MAKD RRNH CGIA SAAS YPTV |
| Gene ID: | 1514 |
| Uniprot: | P07711 |
| Cellular Location: | Lysosome |
| Calculated MW: | 37kDa |
| Observed MW: | 26kDa/38kDa |
| Synonyms: | CTSL, CATL, CTSL1, MEP |
| Background: | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | Important for the overall degradation of proteins in lysosomes. |
| NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P07711 |
| NCBI GenInfo Identifier: | 115741 |
| NCBI Gene ID: | 1514 |
| NCBI Accession: | P07711.2 |
| UniProt Secondary Accession: | P07711,Q6IAV1, Q96QJ0, |
| UniProt Related Accession: | P07711 |
| Molecular Weight: | 38kDa |
| NCBI Full Name: | Cathepsin L1 |
| NCBI Synonym Full Names: | cathepsin L |
| NCBI Official Symbol: | CTSL |
| NCBI Official Synonym Symbols: | MEP; CATL; CTSL1 |
| NCBI Protein Information: | cathepsin L1 |
| UniProt Protein Name: | Cathepsin L1 |
| UniProt Synonym Protein Names: | Cathepsin L; Major excreted protein; MEP |
| UniProt Gene Name: | CTSL |
 | Western blot analysis of extracts of various cell lines, using CTSL antibody (CAB12200) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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