Anti-CTSD Antibody (CAB13292)
- SKU:
- CAB13292
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CTSD Antibody |
| Antibody SKU: | CAB13292 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-412 of human CTSD (NP_001900.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, MCF7, rat liver, rat brain, mouse spleen, mouse brain, mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-412 of human CTSD (NP_001900.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPIP EVLK NYMD AQYY GEIG IGTP PQCF TVVF DTGS SNLW VPSI HCKL LDIA CWIH HKYN SDKS STYV KNGT SFDI HYGS GSLS GYLS QDTV SVPC QSAS SASA LGGV KVER QVFG EATK QPGI TFIA AKFD GILG MAYP RISV NNVL PVFD NLMQ QKLV DQNI FSFY LSRD PDAQ PGGE LMLG GTDS KYYK GSLS YLNV TRKA YWQV HLDQ VEVA SGLT LCKE GCEA IVDT GTSL MVGP VDEV RELQ KAIG AVPL IQGE YMIP CEKV STLP AITL KLGG KGYK LSPE DYTL KVSQ AGKT LCLS GFMG MDIP PPSG PLWI LGDV FIGR YYTV FDRD NNRV GFAE AARL |
| Gene ID: | 1509 |
| Uniprot: | P07339 |
| Cellular Location: | Lysosome, Melanosome, Secreted, extracellular space |
| Calculated MW: | 44kDa |
| Observed MW: | 15kDa/28kDa/43kDa/46kDa |
| Synonyms: | CLN10, CPSD, HEL-S-130P, Cathepsin D, CTSD |
| Background: | This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. |
| UniProt Protein Function: | CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. |
| UniProt Protein Details: | Protein type:Autophagy; Motility/polarity/chemotaxis; Protease; EC 3.4.23.5 Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; lysosome; melanosome; extracellular region Molecular Function:protein binding; aspartic-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis Disease: Ceroid Lipofuscinosis, Neuronal, 10 |
| NCBI Summary: | This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07339 |
| NCBI GenInfo Identifier: | 115717 |
| NCBI Gene ID: | 1509 |
| NCBI Accession: | P07339.1 |
| UniProt Secondary Accession: | P07339,Q6IB57, |
| UniProt Related Accession: | P07339 |
| Molecular Weight: | 44,552 Da |
| NCBI Full Name: | Cathepsin D |
| NCBI Synonym Full Names: | cathepsin D |
| NCBI Official Symbol: | CTSD |
| NCBI Official Synonym Symbols: | CPSD; CLN10; HEL-S-130P |
| NCBI Protein Information: | cathepsin D; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P |
| UniProt Protein Name: | Cathepsin D |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSD |
| UniProt Entry Name: | CATD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CTSD antibody (CAB13292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Western blot analysis of extracts of various cell lines, using CTSD antibody (CAB13292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CTSD Rabbit pAb (CAB13292) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat spleen using CTSD Rabbit pAb (CAB13292) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver using CTSD Rabbit pAb (CAB13292) at dilution of 1:100 (40x lens). |
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