Anti-CTNNBIP1 Antibody (CAB7122)

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SKU:
CAB7122
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-CTNNBIP1 Antibody
Antibody SKU:CAB7122
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human CTNNBIP1 (NP_064633.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human CTNNBIP1 (NP_064633.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNRE GAPG KSPE EMYI QQKV RVLL MLRK MGSN LTAS EEEF LRTY AGVV NSQL SQLP PHSI DQGA EDVV MAFS RSET EDRR Q
Gene ID:56998
Uniprot:Q9NSA3
Cellular Location:Cytoplasm, Nucleus
Calculated MW:9kDa
Observed MW:15kDa
Synonyms:CTNNBIP1, ICAT
Background:The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Inhibitor

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; cytoplasm; nucleus; beta-catenin destruction complex; cytosol

Molecular Function:protein binding; beta-catenin binding

Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; ureteric bud branching; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding

NCBI Summary:The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NSA3
NCBI GenInfo Identifier:59889555
NCBI Gene ID:56998
NCBI Accession:NP_001012329.1
UniProt Secondary Accession:Q9NSA3,Q9JJN6,
UniProt Related Accession:Q9NSA3
Molecular Weight:9,170 Da
NCBI Full Name:beta-catenin-interacting protein 1
NCBI Synonym Full Names:catenin, beta interacting protein 1
NCBI Official Symbol:CTNNBIP1  
NCBI Official Synonym Symbols:ICAT  
NCBI Protein Information:beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; inhibitor of beta-catenin and Tcf-4
UniProt Protein Name:Beta-catenin-interacting protein 1
UniProt Synonym Protein Names:Inhibitor of beta-catenin and Tcf-4
UniProt Gene Name:CTNNBIP1  
UniProt Entry Name:CNBP1_HUMAN
Anti-CTNNBIP1 Antibody (CAB7122)Western blot analysis of extracts of mouse heart, using CTNNBIP1 antibody (CAB7122) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.

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