Anti-CTIP1 Antibody (CAB9231)
- SKU:
- CAB9231
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-CTIP1 Antibody |
| Antibody SKU: | CAB9231 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CTIP1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | A synthesized peptide derived from human CTIP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 53335 |
| Uniprot: | Q9H165 |
| Cellular Location: | |
| Calculated MW: | 120kDa |
| Observed MW: | 100KDa |
| Synonyms: | BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856 |
| Background: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein homodimerization activity; protein heterodimerization activity; metal ion binding; transcription corepressor activity Biological Process: protein sumoylation; transcription, DNA-dependent; B cell differentiation; regulation of dendrite development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of collateral sprouting; negative regulation of transcription from RNA polymerase II promoter; negative regulation of axon extension; positive regulation of collateral sprouting; negative regulation of protein homooligomerization; T cell differentiation |
| NCBI Summary: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H165 |
| NCBI GenInfo Identifier: | 20336307 |
| NCBI Gene ID: | 53335 |
| NCBI Accession: | NP_060484.2 |
| UniProt Secondary Accession: | Q9H165,Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9 Q9NWA7, D6W5D7, |
| UniProt Related Accession: | Q9H165 |
| Molecular Weight: | 91,197 Da |
| NCBI Full Name: | B-cell lymphoma/leukemia 11A isoform 2 |
| NCBI Synonym Full Names: | B-cell CLL/lymphoma 11A (zinc finger protein) |
| NCBI Official Symbol: | BCL11A |
| NCBI Official Synonym Symbols: | EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL |
| NCBI Protein Information: | B-cell lymphoma/leukemia 11A; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (z |
| UniProt Protein Name: | B-cell lymphoma/leukemia 11A |
| UniProt Synonym Protein Names: | B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856 |
| Protein Family: | B-cell lymphoma/leukemia |
| UniProt Gene Name: | BCL11A |
| UniProt Entry Name: | BC11A_HUMAN |
 | Western blot - CTIP1 Rabbit mAb (CAB9231) |
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