Anti-CTBP2 Antibody (CAB16826)
- SKU:
- CAB16826
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CTBP2 Antibody |
| Antibody SKU: | CAB16826 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CTBP2 (NP_001320.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, COS-7, BxPC-3, NIH/3T3, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CTBP2 (NP_001320.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEPF SFAQ GPLK DAPN LICT PHTA WYSE QASL EMRE AAAT EIRR AITG RIPE SLRN CVNK EFFV TSAP WSVI DQQA IHPE LNGA TYRY PPGI VGVA PGGL PAAM EGII PGGI PVTH NLPT VAHP SQAP SPNQ PTKH GDNR EHPN EQ |
| Gene ID: | 1488 |
| Uniprot: | P56545 |
| Cellular Location: | |
| Calculated MW: | 48kDa/56kDa/106kDa |
| Observed MW: | 49kDa |
 | Western blot - CTBP2 Polyclonal Antibody (CAB16826) |
| Synonyms: | CTBP2 |
| Background: | This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | CTBP2: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10q26.13 Cellular Component: transcriptional repressor complex; synapse; cell junction; nucleus Molecular Function:protein binding; retinoic acid receptor binding; transcription coactivator activity; chromatin binding; transcription corepressor activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; white fat cell differentiation; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; viral genome replication; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] |
| UniProt Code: | P56545 |
| NCBI GenInfo Identifier: | 3182976 |
| NCBI Gene ID: | 1488 |
| NCBI Accession: | P56545.1 |
| UniProt Secondary Accession: | P56545,O43449, Q5SQP7, Q69YI3, Q86SV0, Q9H2T8, A8K2X5 D3DRF5, |
| UniProt Related Accession: | P56545 |
| Molecular Weight: | 106,187 Da |
| NCBI Full Name: | C-terminal-binding protein 2 |
| NCBI Synonym Full Names: | C-terminal binding protein 2 |
| NCBI Official Symbol: | CTBP2 |
| NCBI Protein Information: | C-terminal-binding protein 2; ribeye |
| UniProt Protein Name: | C-terminal-binding protein 2 |
| Protein Family: | C-terminal-binding protein |
| UniProt Gene Name: | CTBP2 |
| UniProt Entry Name: | CTBP2_HUMAN |
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