Anti-CSNK1A1 Antibody (CAB16225)

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SKU:
CAB16225
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
Frequently bought together:

Description

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Antibody Name:Anti-CSNK1A1 Antibody
Antibody SKU:CAB16225
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CSNK1A1 (NP_001020276.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HeLa, MCF7, PC-3, Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CSNK1A1 (NP_001020276.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LFNF CSRR FTMK TVLM LADQ MISR IEYV HTKN FIHR DIKP DNFL MGIG RHCN KCLE SPVG KRKR SMTV STSQ DPSF SGLN QLFL IDFG LAKK YRDN RTRQ H
Gene ID:1452
Uniprot:P48729
Cellular Location:Chromosome, Cytoplasm, Nucleus speckle, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center
Calculated MW:37kDa/38kDa/41kDa
Observed MW:38kDa
Synonyms:CSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Background:
UniProt Protein Function:CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.
UniProt Protein Details:

Protein type:Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck

Molecular Function:kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway

UniProt Code:P48729
NCBI GenInfo Identifier:31077177
NCBI Gene ID:1452
NCBI Accession:P48729.2
UniProt Secondary Accession:P48729,Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2 Q9UDK3, D3DQG0, D3DQG1,
UniProt Related Accession:P48729
Molecular Weight:37,567 Da
NCBI Full Name:Casein kinase I isoform alpha
NCBI Synonym Full Names:casein kinase 1 alpha 1
NCBI Official Symbol:CSNK1A1  
NCBI Official Synonym Symbols:CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p  
NCBI Protein Information:casein kinase I isoform alpha
UniProt Protein Name:Casein kinase I isoform alpha
UniProt Synonym Protein Names:CK1
Protein Family:Casein kinase
UniProt Gene Name:CSNK1A1  
UniProt Entry Name:KC1A_HUMAN
Anti-CSNK1A1 Antibody (CAB16225)Western blot analysis of extracts of various cell lines, using CSNK1A1 antibody (CAB16225) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-CSNK1A1 Antibody (CAB16225)Immunohistochemistry of paraffin-embedded human tonsil using CSNK1A1 antibody (CAB16225) at dilution of 1:100 (40x lens).
Anti-CSNK1A1 Antibody (CAB16225)Immunohistochemistry of paraffin-embedded human placenta using CSNK1A1 antibody (CAB16225) at dilution of 1:100 (40x lens).

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