Anti-CREM Antibody (CAB5624)
- SKU:
- CAB5624
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CREM Antibody |
| Antibody SKU: | CAB5624 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, K-562, Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSKC ARKK YIKT NPRQ MTME TVES QHDG SITA SLTE SKSA HVQT QTGQ NSIP ALAQ VAAI AETD ESAE SEGV IDSH KRRE ILSR RPSY RKIL NELS SDVP |
| Gene ID: | 1390 |
| Uniprot: | Q03060 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 11-38kDa |
| Observed MW: | 39kDa |
| Synonyms: | CREM, CREM-2, ICER, hCREM-2 |
| Background: | This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. |
| UniProt Protein Function: | CREM: a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. An important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative splice isoforms allow this protein to exert spatial and temporal specificity to cAMP responsiveness. Twentyeight alternatively spliced isoforms of the human protein have been described, with some of them functioning as activators and some as repressors of transcription. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; DNA binding; cAMP response element binding protein binding; transcription factor activity Biological Process: response to cAMP; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; spermatogenesis; glycosphingolipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; signal transduction; cell differentiation; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03060 |
| NCBI GenInfo Identifier: | 259016392 |
| NCBI Gene ID: | 1390 |
| NCBI Accession: | Q03060.5 |
| UniProt Secondary Accession: | Q03060,O75519, Q14501, A8K014, A8K3J7, A8K6A1, A8MPQ2 B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, |
| UniProt Related Accession: | Q03060 |
| Molecular Weight: | 361 |
| NCBI Full Name: | cAMP-responsive element modulator |
| NCBI Synonym Full Names: | cAMP responsive element modulator |
| NCBI Official Symbol: | CREM |
| NCBI Official Synonym Symbols: | ICER; CREM-2; hCREM-2 |
| NCBI Protein Information: | cAMP-responsive element modulator; CREM 2beta-a protein; CREM 2alpha-b protein; cAMP response element modulator; inducible cAMP early repressor ICER |
| UniProt Protein Name: | cAMP-responsive element modulator |
| UniProt Synonym Protein Names: | Inducible cAMP early repressor; ICER |
| Protein Family: | cAMP-responsive element modulator |
| UniProt Gene Name: | CREM |
| UniProt Entry Name: | CREM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CREM antibody (CAB5624) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using CREM antibody (CAB5624) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using CREM antibody (CAB5624) at dilution of 1:100 (40x lens). |
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