Anti-CPT1A Antibody (CAB5307)
- SKU:
- CAB5307
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-CPT1A Antibody |
| Antibody SKU: | CAB5307 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 497-756 of human CPT1A (NP_001027017.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IP 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, HepG2, Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 497-756 of human CPT1A (NP_001027017.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GYAE DGHC KGDI NPNI PYPT RLQW DIPG ECQE VIET SLNT ANLL ANDV DFHS FPFV AFGK GIIK KCRT SPDA FVQL ALQL AHYK DMGK FCLT YEAS MTRL FREG RTET VRSC TTES CDFV RAMV DPAQ TVEQ RLKL FKLA SEKH QHMY RLAM TGSG IDRH LFCL YVVS KYLA VESP FLKE VLSE PWRL STSQ TPQQ QVEL FDLE NNPE YVSS GGGF GPVA DDGY GVSY ILVG ENLI NFHI SSKF SCPE TGII SQGP SSDT |
| Gene ID: | 1374 |
| Uniprot: | P50416 |
| Cellular Location: | Mitochondrion outer membrane, Multi-pass membrane protein |
| Calculated MW: | 86kDa/88kDa |
| Observed MW: | 88kDa |
| Synonyms: | CPT1A, CPT1, CPT1-L, L-CPT1 |
| Background: | The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane Molecular Function:identical protein binding; carnitine O-palmitoyltransferase activity Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization Disease: Carnitine Palmitoyltransferase I Deficiency |
| NCBI Summary: | The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50416 |
| NCBI GenInfo Identifier: | 56405343 |
| NCBI Gene ID: | 1374 |
| NCBI Accession: | P50416.2 |
| UniProt Secondary Accession: | P50416,Q8TCU0, Q9BWK0, |
| UniProt Related Accession: | P50416 |
| Molecular Weight: | 773 |
| NCBI Full Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
| NCBI Synonym Full Names: | carnitine palmitoyltransferase 1A (liver) |
| NCBI Official Symbol: | CPT1A |
| NCBI Official Synonym Symbols: | CPT1; CPT1-L; L-CPT1 |
| NCBI Protein Information: | carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform |
| UniProt Protein Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
| UniProt Synonym Protein Names: | Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A |
| Protein Family: | Carnitine O-palmitoyltransferase |
| UniProt Gene Name: | CPT1A |
| UniProt Entry Name: | CPT1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPT1A antibody (CAB5307) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using CPT1A Rabbit pAb (CAB5307) at dilution of 1:100 (40x lens). |
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