Anti-CPN1 Antibody (CAB7887)
- SKU:
- CAB7887
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CPN1 Antibody |
| Antibody SKU: | CAB7887 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-458 of human CPN1 (NP_001299.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Raji, Mouse liver, Mouse pancreas, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-458 of human CPN1 (NP_001299.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FVLS ANLH GGAV VANY PYDK SFEH RVRG VRRT ASTP TPDD KLFQ KLAK VYSY AHGW MFQG WNCG DYFP DGIT NGAS WYSL SKGM QDFN YLHT NCFE ITLE LSCD KFPP EEEL QREW LGNR EALI QFLE QVHQ GIKG MVLD ENYN NLAN AVIS VSGI NHDV TSGD HGDY FRLL LPGI YTVS ATAP GYDP ETVT VTVG PAEP TLVN FHLK RSIP QVSP VRRA PSRR HGVR AKVQ PQAR KKEM EMRQ LQRG PA |
| Gene ID: | 1369 |
| Uniprot: | P15169 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 52kDa |
| Observed MW: | 52kDa |
| Synonyms: | CPN1, CPN, SCPN |
| Background: | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. |
| UniProt Protein Function: | CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family. |
| UniProt Protein Details: | Protein type:Secreted; EC 3.4.17.3; Protease; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q24.2 Molecular Function:serine carboxypeptidase activity Biological Process: peptide metabolic process; protein processing Disease: Carboxypeptidase N Deficiency |
| NCBI Summary: | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15169 |
| NCBI GenInfo Identifier: | 115896 |
| NCBI Gene ID: | 1369 |
| NCBI Accession: | P15169.1 |
| UniProt Secondary Accession: | P15169,B1AP59, |
| UniProt Related Accession: | P15169 |
| Molecular Weight: | 52,286 Da |
| NCBI Full Name: | Carboxypeptidase N catalytic chain |
| NCBI Synonym Full Names: | carboxypeptidase N subunit 1 |
| NCBI Official Symbol: | CPN1 |
| NCBI Official Synonym Symbols: | CPN; SCPN |
| NCBI Protein Information: | carboxypeptidase N catalytic chain |
| UniProt Protein Name: | Carboxypeptidase N catalytic chain |
| UniProt Synonym Protein Names: | Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN |
| Protein Family: | Carboxypeptidase |
| UniProt Gene Name: | CPN1 |
| UniProt Entry Name: | CBPN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CPN1 antibody (CAB7887) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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