Anti-CPLX2 Antibody (CAB7774)

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SKU:
CAB7774
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Frequently bought together:

Description

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Antibody Name:Anti-CPLX2 Antibody
Antibody SKU:CAB7774
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDFV MKQA LGGA TKDM GKML GGEE EKDP DAQK KEEE RQEA LRQQ EEER KAKH ARME AERE KVRQ QIRD KYGL KKKE EKEA EEKA ALEQ PCEG SLTR PKKA IPAG CGDE EEEE EESI LDTV LKYL PGPL QDMF KK
Gene ID:10814
Uniprot:Q6PUV4
Cellular Location:Cytoplasm, cytosol
Calculated MW:15kDa
Observed MW:15kDa
Synonyms:CPLX2, 921-L, CPX-2, CPX2, Hfb1
Background:Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:CPLX2: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: mast cell granule; cell soma; dendrite; synapse; cytosol

Molecular Function:syntaxin-1 binding; calcium-dependent protein binding

Biological Process: regulation of exocytosis; nervous system development; synaptic vesicle exocytosis; positive regulation of synaptic plasticity; mast cell degranulation; cell differentiation; vesicle docking during exocytosis

NCBI Summary:Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q6PUV4
NCBI GenInfo Identifier:51316998
NCBI Gene ID:10814
NCBI Accession:Q6PUV4.2
UniProt Secondary Accession:Q6PUV4,O09056, Q13329, Q28184, Q52M15, Q64386, B2RAG2
UniProt Related Accession:Q6PUV4
Molecular Weight:15,394 Da
NCBI Full Name:Complexin-2
NCBI Synonym Full Names:complexin 2
NCBI Official Symbol:CPLX2  
NCBI Official Synonym Symbols:CPX2; Hfb1; 921-L; CPX-2  
NCBI Protein Information:complexin-2; CPX II; complexin II; synaphin 1; synaphin-1
UniProt Protein Name:Complexin-2
UniProt Synonym Protein Names:Complexin II; CPX II; Synaphin-1
Protein Family:Complexin
UniProt Gene Name:CPLX2  
UniProt Entry Name:CPLX2_HUMAN
Anti-CPLX2 Antibody (CAB7774)Western blot analysis of extracts of various cell lines, using CPLX2 antibody (CAB7774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.

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